Macrophage Vesicles‐Loaded NIR‐II AIEgens for Precise In Situ Fluorescence Imaging of Atherosclerosis DOI

Zhiheng Luo,

Xipeng Li,

Caifa You

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: June 2, 2025

Precise diagnosis of atherosclerosis (AS) is a crucial strategy for reducing acute cardiovascular events. Herein, macrophage membrane (MM)-camouflaged biomimetic vesicle loaded with near-infrared-II (NIR-II) aggregation-induced emission luminogens (AIEgens) (P4TT@MM) proposed to achieve localized in vivo imaging atherosclerosis. The AIEgens characteristics P4TT@MM effectively compensate the fluorescence intensity decrease caused by intramolecular torsional charge transfer (TICT) effect, even foam cell-rich lesions. Benefiting from camouflage MM and its strong affinity atherosclerotic plaques, enables precise targeting lesion sites, successfully achieving high-contrast plaques carotid arteries aortas AS mice model. Compared free P4TT, NIR-II increased 140% 152% aortas, respectively. Moreover, demonstrates robust biocompatibility combined significant clinical translation potential. This study may present promising tool AS.

Language: Английский

A triple-targeting and viscosity-sensitive fluorescence probe for visualization of liver injury and tumor models DOI
Lei Peng, Pengfei Wei, Chuan Dong

et al.

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137614 - 137614

Published: March 1, 2025

Language: Английский

Citations

1
Polarity, pH and HClO triple-response fluorescent probe and its application in inflammation models DOI

Ying Liu,

Weiling Yan,

Jingyu Li

et al.

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 126953 - 126953

Published: Jan. 1, 2025

Language: Английский

Citations

0
Multi-component driven fluorescence composite nanospheres coating strategy: Spectral properties, release, tumor imaging and bioactivity evaluation in a simulated gastrointestinal microenvironment DOI

Mengtong Zhang,

Tiantian Chai,

Shuo Wang

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 333, P. 125858 - 125858

Published: Feb. 5, 2025

Language: Английский

Citations

0
An Insight to Nanoliposomes as Smart Radiopharmaceutical Delivery Tools for Imaging Atherosclerotic Plaques: Positron Emission Tomography Applications DOI Creative Commons
Reabetswe Sebatana,

Kahwenga D. Kudzai,

Allan Magura

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 240 - 240

Published: Feb. 12, 2025

Atherosclerosis is a chronic progressive disease which known to cause acute cardiovascular events as well cerebrovascular with high mortality. Unlike many other diseases, atherosclerosis often diagnosed only after an or fatal event. At present, the clinical problems of mainly involve difficulty in confirming plaques identifying stability early phase. In recent years, development nanotechnology has come various advantages including non-invasive imaging enhancement, can be studied for atherosclerosis. For targeted and treatment, nanoliposomes provide enhanced stability, drug administration, extended circulation, less toxicity. This review discusses current advances tailored liposomal nano-radiopharmaceutical-based techniques their applications atherosclerotic plaque diagnosis. further highlights nano-radiopharmaceutical localisation biodistribution-key processes pathophysiology Finally, this direction future nano-radiopharmaceuticals potential tool assessment diagnosis plaque.

Language: Английский

Citations

0
Endoplasmic reticulum (ER)-targeted ratiometric fluorescent probe for visualization of ER-phagy induced by ONOO- and NIR imaging in mice with drug-induced liver injury DOI
Lei Peng, Ni Wu, Zhi Yan

et al.

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 283, P. 117525 - 117525

Published: April 28, 2025

Language: Английский

Citations

0
Macrophage Vesicles‐Loaded NIR‐II AIEgens for Precise In Situ Fluorescence Imaging of Atherosclerosis DOI

Zhiheng Luo,

Xipeng Li,

Caifa You

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: June 2, 2025

Precise diagnosis of atherosclerosis (AS) is a crucial strategy for reducing acute cardiovascular events. Herein, macrophage membrane (MM)-camouflaged biomimetic vesicle loaded with near-infrared-II (NIR-II) aggregation-induced emission luminogens (AIEgens) (P4TT@MM) proposed to achieve localized in vivo imaging atherosclerosis. The AIEgens characteristics P4TT@MM effectively compensate the fluorescence intensity decrease caused by intramolecular torsional charge transfer (TICT) effect, even foam cell-rich lesions. Benefiting from camouflage MM and its strong affinity atherosclerotic plaques, enables precise targeting lesion sites, successfully achieving high-contrast plaques carotid arteries aortas AS mice model. Compared free P4TT, NIR-II increased 140% 152% aortas, respectively. Moreover, demonstrates robust biocompatibility combined significant clinical translation potential. This study may present promising tool AS.

Language: Английский

Citations

0