Biomineralization of Copper‐Celastrol Nanohybrids for Synergistic Antitumor Therapy DOI Open Access
Yifan Li, Na Wang, Hanrong Li

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract The therapeutic potential of celastrol (Cel) in cancer treatment has been constrained by its intrinsic hydrophobicity and the lack efficient delivery systems. Herein, a biomineralization‐based strategy is introduced to construct hybrid nanoparticles (Cel‐TA‐Cu NP) via Cel‐Cu 2 ⁺ coordination, followed TA‐Cu crosslinking. Biomineralization, nature‐inspired process facilitating controlled assembly inorganic–organic structures, enables Cel form coordination complexes with Cu ⁺, which subsequently serve as nucleation sites for tannic acid‐mediated copper mineralization. Unlike conventional nanocarriers, this approach exploits metal‐binding capacity induce spontaneous mineralization, where serves both center drug encapsulation agent chemodynamic therapy (CDT). pH‐responsive dissociation metal‐phenolic ensures tumor‐specific release, while biomineralization inherently enhances aqueous stability bioavailability. Moreover, rational design Cel‐TA‐Cu NP synergistic anticancer effect simultaneously triggering apoptotic signaling pathways amplifying oxidative stress‐induced cytotoxicity. Overall, nanoplatform not only overcomes inherent limitations but also integrates CDT markedly enhance efficacy, providing promising avenue advanced treatment.

Language: Английский

Biomineralization of Copper‐Celastrol Nanohybrids for Synergistic Antitumor Therapy DOI Open Access
Yifan Li, Na Wang, Hanrong Li

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract The therapeutic potential of celastrol (Cel) in cancer treatment has been constrained by its intrinsic hydrophobicity and the lack efficient delivery systems. Herein, a biomineralization‐based strategy is introduced to construct hybrid nanoparticles (Cel‐TA‐Cu NP) via Cel‐Cu 2 ⁺ coordination, followed TA‐Cu crosslinking. Biomineralization, nature‐inspired process facilitating controlled assembly inorganic–organic structures, enables Cel form coordination complexes with Cu ⁺, which subsequently serve as nucleation sites for tannic acid‐mediated copper mineralization. Unlike conventional nanocarriers, this approach exploits metal‐binding capacity induce spontaneous mineralization, where serves both center drug encapsulation agent chemodynamic therapy (CDT). pH‐responsive dissociation metal‐phenolic ensures tumor‐specific release, while biomineralization inherently enhances aqueous stability bioavailability. Moreover, rational design Cel‐TA‐Cu NP synergistic anticancer effect simultaneously triggering apoptotic signaling pathways amplifying oxidative stress‐induced cytotoxicity. Overall, nanoplatform not only overcomes inherent limitations but also integrates CDT markedly enhance efficacy, providing promising avenue advanced treatment.

Language: Английский

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