Robust Acid-Responsive AILE Luminescence Effect Nanoparticle for Drug Release Monitoring and Induction of Apoptosis in Cancer Cells

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Through the PFOEP-SO3(−) + multidrug molecules constructed nanoparticle (NP) experiments and validated by molecular simulation docking experiments, we propose a interaction principle for inducing aggregation-induced locally excited emission (AILE) luminescence from fluorenone (FO)-based conjugated polymers (CPs). Based on this mechanism, NP built π–π stacking. The NPs demonstrate facile synthesis, robust stability, high drug-loading efficiency, enabling tumor-specific drug release in acidic lysosomal environments (pH 3.8–4.7) to minimize off-target toxicity. Concurrently, PFOEPA exhibit pH-dependent fluorescence enhancement: incorporation induces structural reorganization into "sandwich" configuration, amplifying with blue shift under neutral/alkaline conditions, while acidic-triggered protonation collapse disrupts NPs. Moreover, it can be used as an indicator monitoring release, is accompanied changes during process. This possesses multiple functions expected serve effective pH-responsive delivery system.

Language: Английский

Hybrid Systems of Gels and Nanoparticles for Cancer Therapy: Advances in Multifunctional Therapeutic Platforms

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 170 - 170

Published: Feb. 26, 2025

Cancer is a global health concern. Various therapeutic approaches, including chemotherapy, photodynamic therapy, and immunotherapy, have been developed for cancer treatment. Silica nanoparticles, quantum dots, metal–organic framework (MOF)-based nanomedicines gained interest in therapy because of their selective accumulation tumors via the enhanced permeability retention (EPR) effect. However, bare nanoparticles face challenges poor biocompatibility, low stability, limited drug-loading capacity, rapid clearance by reticuloendothelial system (RES). Gels with unique three-dimensional network structures formed through various interactions such as covalent hydrogen bonds are emerging promising materials addressing these challenges. Gel hybridization enhances facilitates controlled drug release, confers cancer-targeting abilities to nanoparticles. This review discusses gel–nanoparticle hybrid systems treatment past five years analyzes roles gels systems.

Language: Английский

Safe-by-design strategies towards bismuth-based nanomaterials in tumor diagnosis and therapy

Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102714 - 102714

Published: March 15, 2025

Language: Английский