New Insights into the Toxicity of Lanthanides with Functional Genomics DOI Creative Commons
Roger M. Pallares, Rebecca J. Abergel

Toxicology, Journal Year: 2024, Volume and Issue: 509, P. 153967 - 153967

Published: Oct. 9, 2024

As the use of lanthanides increases in many industries, concerns regarding their impact on human health rise. However, until recently, toxicological profile these elements had been incompletely characterized, with most studies relying biodistribution assessments and lethal dose determinations different animal models. In last few years, f-element field has started to pivot towards other examination types that identify cellular molecular mechanisms toxicity a high-throughput manner. Under this new paradigm, functional genomics techniques, which rely genetically modified cells or model organisms missing genes proteins, are becoming fundamental gain novel insights into genetic proteomic bases lanthanide toxicity, as well potential therapeutic targets minimize harmful effects metals. This review aims provide an updated perspective current efforts using characterize biological improve safety industrial applications.

Language: Английский

Molecular Engineering of a SICTERS Small Molecule with Superior In Vivo Raman Imaging and Photothermal Performance DOI
Yongming Zhang, Wenxian Zhang, Yuanyuan Qiu

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Raman-based theranostics has demonstrated great potential for sensitive real-time imaging and treatment. However, these advanced materials, primarily depending on the SERS technique, encounter clinical concerns regarding substrate biosafety. Herein, we molecularly engineered a de novo substrate-free SICTERS small molecule, namely BTT–TPA (bis-thienyl-substituted benzotriazole selenadiazole derivative structures), possessing both ultrasensitive Raman signals excellent photothermal effects based self-stacking. The mechanistic studies confirm that BTT maintains planar structure with polycyclic distorted vibrations required SICTERS. TPA enhances donor–acceptor interaction, yielding sensitivity of higher than previously reported molecules; it also acts as molecular rotor, increasing conversion efficiency to 67.44%, which is superior most existing SERS-based materials. In tumor model mouse orthotopic colon cancer, NPs demonstrate imaging-guided therapy effect in eliminating primary metastatic tumors, remarkably decreasing recurrence rate. This work puts forward molecules toward theranostic applications vivo.

Language: Английский

Citations

1
Design Considerations for Organ-Selective Nanoparticles DOI
Min‐Jun Baek, Won Hur, Satoshi Kashiwagi

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Nanoparticles (NPs) have been extensively researched for targeted diagnostic imaging and drug delivery, yet their clinical translation remains limited, with only a few achieving Food Drug Administration approval. This limited success is primarily due to challenges in precise organ- or tissue-specific targeting, which arise from off-target tissue accumulation suboptimal clearance profiles. Herein we examine the critical role of physicochemical properties, including size, surface charge, shape, elasticity, hardness, density, governing biodistribution, targetability, NPs. We highlight recent advancements engineering NPs showcasing both significant progress remaining field nanomedicine. Additionally, discuss emerging tools technologies that are being developed address these challenges. Based on insights materials science, biomedical engineering, computational biology, research, propose key design considerations next-generation nanomedicines enhanced organ selectivity.

Language: Английский

Citations

1
An update review on biopolymer Xanthan gum: Properties, modifications, nanoagrochemicals, and its versatile applications in sustainable agriculture DOI

Zhicheng Zheng,

Zhaoju Sun,

Mei Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136562 - 136562

Published: Oct. 16, 2024

Language: Английский

Citations

9
New Approach Methods (NAMs) for Genotoxicity Assessment of Nano- and Advanced Materials; Advantages and Challenges DOI

Arno C Gutleb,

Sivakumar Murugadoss,

Maciej Stępnik

et al.

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Journal Year: 2025, Volume and Issue: unknown, P. 503867 - 503867

Published: March 1, 2025

Language: Английский

Citations

0
The nano-paradox: addressing nanotoxicity for sustainable agriculture, circular economy and SDGs DOI Creative Commons

Vijay Rani Rajpal,

Byonkesh Nongthongbam,

Manika Bhatia

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 24, 2025

Engineered nanomaterials (ENMs) have aroused extensive interest in agricultural, industrial, and medical applications. The integration of ENMs into the agricultural systems aligns with principles United Nations' sustainable development goals (SDGs), circular economy (CE) bio-economy (BE) principles. This approach offers excellent opportunities to enhance productivity address global climate change challenges. revelation adverse effects (NMs) on various organisms ecosystems, however, has fueled debate 'Nano-paradox' leading emergence a new research domain 'Nanotoxicology'. shown different interactions biological environmental as compared their bulk counterparts. They bioaccumulate organisms, soils, other matrices, move through food chains reach higher trophic levels including humans ultimately resulting oxidative stress cellular damage. Understanding nano-bio interactions, mechanism gene- cytotoxicity, associated potential hazards, is therefore, essential mitigate toxicological outputs. review comprehensively examines cyto- genotoxicity mechanisms systems, covering aspects such entry, uptake, responses, dynamic environments long-term risk assessment (ERA). It also discusses methods, regulatory policies, strategies for toxicity management/mitigation future directions nanotechnology, all within context SDGs, CE, promoting resource efficiency sustainability. Navigating nano-paradox involves balancing benefits concerns about nanotoxicity. Prioritizing thorough above facets can ensure sustainability safety, enabling responsible harnessing nanotechnology's transformative applications mitigating enhancing productivity.

Language: Английский

Citations

0
Clinical translation of quantum dots DOI
Roger M. Pallares, Fabian Kießling, Twan Lammers

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 3

Published: Sept. 30, 2024

Language: Английский

Citations

0
New Insights into the Toxicity of Lanthanides with Functional Genomics DOI Creative Commons
Roger M. Pallares, Rebecca J. Abergel

Toxicology, Journal Year: 2024, Volume and Issue: 509, P. 153967 - 153967

Published: Oct. 9, 2024

As the use of lanthanides increases in many industries, concerns regarding their impact on human health rise. However, until recently, toxicological profile these elements had been incompletely characterized, with most studies relying biodistribution assessments and lethal dose determinations different animal models. In last few years, f-element field has started to pivot towards other examination types that identify cellular molecular mechanisms toxicity a high-throughput manner. Under this new paradigm, functional genomics techniques, which rely genetically modified cells or model organisms missing genes proteins, are becoming fundamental gain novel insights into genetic proteomic bases lanthanide toxicity, as well potential therapeutic targets minimize harmful effects metals. This review aims provide an updated perspective current efforts using characterize biological improve safety industrial applications.

Language: Английский

Citations

0