ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

This study investigates the use of bimetallic copper-silver nanoclusters (Cu-AgNCs) for fluorescence turn-on sensing leucine, a potential biomarker cancer detection. These exhibit high tunability and specificity, with Fe3+ serving as quencher to facilitate leucine The recovery mechanism is attributed interaction Fe3+, alleviating quenching effect on metal nanoclusters. nanocluster promising platform identification in diagnosis. enhancement upon binding provides measurable signal, confirming feasibility these noninvasive sensors biomarkers. sensor achieves detection limit 0.58 μM demonstrates linear response within range 110-657 μM. approach offers method diagnostics using saliva urine samples. Additionally, method's reproducibility robustness further support its clinical applications, providing cost-effective accessible technique early

Language: Английский