Tetrahedron, Journal Year: 2024, Volume and Issue: unknown, P. 134359 - 134359
Published: Nov. 1, 2024
Language: Английский
The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 6, 2025
A water-controlled geminal phosphinoylation of enaminones with H-phosphine oxides has been established through AlCl3-mediated C-N bond cleavage in this work, which provides a novel strategy for accessing various hydroxy and diphosphinoyl products 3a 4a high yields. The transformation features excellent functional group tolerance, operational simplicity, atom economy, is amenable complex molecule skeletons. Preliminary mechanism studies suggest the conversion from to involve elimination hydroxyl group, water temperature plays critical role influencing reaction pathway product selectivity. This research significant value functionalization enaminones.
Language: Английский
Citations
0
Tetrahedron Letters, Journal Year: 2024, Volume and Issue: 149, P. 155266 - 155266
Published: Aug. 22, 2024
Language: Английский
Citations
2
Organic Letters, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 18, 2024
A regioselective radical α,γ-diphosphinylation of allylamines with secondary phosphine oxides by photoinduced cobaloxime catalysis is described. The reaction tolerates a wide range and oxides, affording α-amino diphosphine dioxides in moderate to good yields hydrogen evolution. synthesis new monoxide ligands the promising antitumor activities products demonstrate great potential applications this approach drug discovery. detailed mechanism studies indicate that likely proceeds through dehydrogenative allylic phosphinylation nucleophilic addition process.
Language: Английский
Citations
1
Tetrahedron, Journal Year: 2024, Volume and Issue: unknown, P. 134359 - 134359
Published: Nov. 1, 2024
Language: Английский
Citations
0