Mo-Mediated Reductive Cyclization/Allylation of 2-Alkynyl Nitroarenes with 1,3-Dienes: Synthesis of 3-Allylindoles

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

3-Allylindoles constitute a key structural feature in many natural products and bioactive compounds. In this work, we developed Mo-mediated reductive cyclization/allylation of 2-alkynyl nitroarenes with 1,3-dienes. Using Mo(CO)6 as both the reductant catalyst, broad range functionalized 3-allylindoles were prepared good to excellent yields from easily available 2-alkynylnitroarenes 1,3-dienes starting materials.

Language: Английский

PhICl₂/KSeCN Mediated Synthesis of Selenopheno[3,2-b]indoles and 3-Selenocyanato-2-benzoselenophene Indoles from 1,3-Diynes via Double Electrophilic Cyclization

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

A hypervalent iodine-enabled double intramolecular electrophilic cyclization of 1,3-diynes has been employed in the synthesis selenopheno[3,2-b]indoles and 3-selenocyanato-2-benzoselenophene indoles. plausible mechanism involving situ formation reactive Cl-SeCN species from reaction PhICl2 KSeCN, followed by cascade C-N/C-Se bond formations, was postulated.

Language: Английский