4-Alkyl-4H-thieno[2′,3′:4,5]pyrrolo[2,3-b]quinoxaline Derivatives as New Heterocyclic Analogues of Indolo[2,3-b]quinoxalines: Synthesis and Antitubercular Activity DOI Open Access

Gusein A. o. Sadykhov,

Danila V. Belyaev,

Ekaterina E. Khramtsova

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 369 - 369

Published: Jan. 3, 2025

The synthetic approach based on a sequence of Buchwald–Hartwig cross-coupling and annulation through intramolecular oxidative cyclodehydrogenation has been used for the construction novel 4-alkyl-4H-thieno[2′,3′:4,5]pyrrolo[2,3-b]quinoxaline derivatives. For first time, these polycyclic compounds were evaluated antimycobacterial activity, including extensively drug-resistant strains. A reasonable bacteriostatic effect against Mycobacterium tuberculosis H37Rv was demonstrated. plausible mechanism activity heterocyclic analogues indolo[2,3-b]quinoxalines advanced basis their molecular docking data.

Language: Английский

4-Alkyl-4H-thieno[2′,3′:4,5]pyrrolo[2,3-b]quinoxaline Derivatives as New Heterocyclic Analogues of Indolo[2,3-b]quinoxalines: Synthesis and Antitubercular Activity DOI Open Access

Gusein A. o. Sadykhov,

Danila V. Belyaev,

Ekaterina E. Khramtsova

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 369 - 369

Published: Jan. 3, 2025

The synthetic approach based on a sequence of Buchwald–Hartwig cross-coupling and annulation through intramolecular oxidative cyclodehydrogenation has been used for the construction novel 4-alkyl-4H-thieno[2′,3′:4,5]pyrrolo[2,3-b]quinoxaline derivatives. For first time, these polycyclic compounds were evaluated antimycobacterial activity, including extensively drug-resistant strains. A reasonable bacteriostatic effect against Mycobacterium tuberculosis H37Rv was demonstrated. plausible mechanism activity heterocyclic analogues indolo[2,3-b]quinoxalines advanced basis their molecular docking data.

Language: Английский

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