Photocatalytic Difunctionalization of [1.1.1]Propellane

The Chemical Record, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

The hunt for new molecular structures to improve the efficacy of biologically active molecules is at forefront pharmaceutical chemistry. So synthetic chemists have always been busy in last few decades synthesizing and testing frameworks which would work as more efficient bioisosteres present bioactive functional groups. In this area, bicyclo[1.1.1]pentane (BCP) framework has identified a promising candidate. It being utilized bioisostere aryl, tert-butyl, alkynes, etc. Now major precursor various BCP derivatives [1.1.1]propellane functionalization drawn widespread attention organic chemist community. Over past two decades, use visible light synthesis rapidly gained popularity, it represents one most approaches aligned with principles green sustainable chemistry, several interesting papers covering photocatalytic difunctionalization also published decade. This particular field really attracted That why we decided compile review article articles related under conditions. Here review, categorized discussed three categories, namely i) without using any catalyst, ii) organocatalysts, iii) metal catalysts deeper understanding key aspects these transformations.

Language: Английский

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Silver-catalyzed direct decarboxylative C H functionalization of azauracils with aliphatic carboxylic acids

Tetrahedron Letters, Journal Year: 2025, Volume and Issue: unknown, P. 155619 - 155619

Published: April 1, 2025

Language: Английский

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Photocatalytic Diheteroarylation of [1.1.1]Propellane for the Construction of 1,3-Diheteroaryl Bicyclo[1.1.1]pentanes

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Herein, we report a visible light-induced diheteroarylation reaction of [1.1.1]propellane to synthesize 1,3-diheteroaryl bicyclo[1.1.1]pentanes (BCPs). In this approach, heteroaryl radicals are generated from halides via photocatalysis and subsequently added [1.1.1]propellane. The

Language: Английский

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Photochemical alkylation of quinoxalin-2(1H)-ones with N,N,N′,N′-tetraalkylethylenediamine

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A visible-light-induced C-3 alkylation of quinoxalin-2(1 H )-ones with N , ′, ′-tetraalkylethylenediamine was achieved without an external photocatalyst.

Language: Английский

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Photochemical direct C3 cyanoalkylation of quinoxalin-2(1H)-ones with cyclobutanone oxime esters under catalyst-free conditions

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: 153, P. 155363 - 155363

Published: Nov. 12, 2024

Language: Английский

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