Ferrocene-containing tetrahydropyridazines via domino chemistry

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142145 - 142145

Published: March 1, 2025

Access to C5-Sulfonylated Tetrahydropyridazines via Photoinduced Cascade Sulfonylation-Cyclization of N-Cinnamyl Aldehyde Hydrazones

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Direct installation of a sulfonyl functional group into the C5-position tetrahydropyridazine was achieved using N'-benzylidene-N-cinnamylacetohydrazide as new building skeleton via photocatalytic carbosulfonylation/annulation procedure. Various substituted C5-sulfonylated tetrahydropyridazines were obtained in good to excellent yields employing aryl- or alkylsulfonyl chlorides radical sources. This reaction realized through selective addition C2 position cinnamyl followed by 6-endo-trig annulation hydrazone CH═N bond.

Language: Английский

Visible Light-Induced Radical-Cascade Difluoroalkylation/Cyclization of Unsaturated Aldehyde Hydrazones for the Synthesis of Difluoroalkylated Dihydropyrazoles and Tetrahydropyridazines

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: June 5, 2025

Visible light-induced radical 5/6-endo-trig difluoroalkylation/cyclization of N-allyl and homoallyl aldehyde hydrazones with various fluoroalkyl bromides has been achieved. The reaction was carried out alkyl difluoroacetates difluoroacetamide as difluoroalkylation reagents Eosin Y an organic photocatalyst. Various difluoroalkylated dihydropyrazoles tetrahydropyridazines were obtained under metal-free mild conditions.

Language: Английский