Catalyst‐Free Photooxidative N‐Acylation of Azoles with Aldehydes
Nianfeng Gong,
No information about this author
Zelin Zhao,
No information about this author
David James Young
No information about this author
et al.
Chemistry - A European Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
Abstract
A
catalyst‐free
photochemical
N‐acylation
of
azoles
with
aldehydes
has
been
developed
using
inexpensive
BrCCl
3
as
the
oxidant.
This
transition‐metal‐
and
photocatalyst‐free
amidation
proceeded
efficiently
a
wide
variety
substrates
to
give
corresponding
N‐acylazoles,
including
for
late
modification
pharmaceutically
active
molecules,
on
gram‐scale.
Language: Английский
Visible-Light-Induced Synthesis of Esters via a Self-Propagating Radical Reaction
Zelin Zhao,
No information about this author
Wenping Li,
No information about this author
Qiujie Shan
No information about this author
et al.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
90(4), P. 1616 - 1627
Published: Jan. 16, 2025
We
herein
disclose
a
visible-light-induced
synthesis
of
O-aryl
esters
through
the
cross-dehydrogenative
coupling
aldehydes
with
phenols
using
BrCCl3,
in
which
phenolate
functions
as
both
substrate
and
photosensitizer.
This
transition-metal-
photocatalyst-free
esterification
is
suitable
for
wide
range
substrates
gives
moderate
to
excellent
yields
(up
95%).
Mechanistic
studies
provided
evidence
self-propagating
radical
reaction
involving
homolytic
cleavage
aldehydic
C–H
bond
formation
acyl
bromides.
BrCCl3
serves
an
oxidant
hydrogen
atom
transfer
(HAT)
agent.
Language: Английский