Ruthenium-Catalyzed Intramolecular Allene–alkyne Cascade Cyclization: Access to the Sulfone-cyclopenta[a]naphthalene Core DOI
P. R. SINGH,

Deepshikha Deepshikha,

Nand Lal

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: 27(5), P. 1153 - 1158

Published: Jan. 29, 2025

A ruthenium-catalyzed intramolecular cascade cyclization of allene-alkyne has been achieved. This method offers a streamlined and atom-economical approach for the construction sulfone bearing 1H-cyclopenta[a]naphthalenes, an important structural scaffold that exists in biologically active compounds. Our approach, backed by mechanistic insights from deuterium labeling, DFT calculations, potential reaction scale-up, presents synthetic chemists with invaluable tool efficiently producing distinct carbon framework one-pot manner. protocol is operationally simple, exhibiting broad substrate scope consistently high yields.

Language: Английский

Ruthenium-Catalyzed Intramolecular Allene–alkyne Cascade Cyclization: Access to the Sulfone-cyclopenta[a]naphthalene Core DOI
P. R. SINGH,

Deepshikha Deepshikha,

Nand Lal

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: 27(5), P. 1153 - 1158

Published: Jan. 29, 2025

A ruthenium-catalyzed intramolecular cascade cyclization of allene-alkyne has been achieved. This method offers a streamlined and atom-economical approach for the construction sulfone bearing 1H-cyclopenta[a]naphthalenes, an important structural scaffold that exists in biologically active compounds. Our approach, backed by mechanistic insights from deuterium labeling, DFT calculations, potential reaction scale-up, presents synthetic chemists with invaluable tool efficiently producing distinct carbon framework one-pot manner. protocol is operationally simple, exhibiting broad substrate scope consistently high yields.

Language: Английский

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