Reverse Block Sequence in Self-Immolative Poly(benzyl ether)-Based Amphiphiles for Tailoring End Groups and Self-Assembly Behavior DOI

Ji Woo Kim,

Tae-Il Kang,

Eunpyo Choi

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

This paper reports a modular design of self-immolative poly(benzyl ether) (PBE) amphiphiles that allows precise control over polymer chain structure, end-group placement, and degradation behavior. By tuning block sequences exposing reactive end groups, these undergo efficient head-to-tail depolymerization upon external stimuli. Structural variations in the monomers enable micelle formation with groups displayed on surface, while carboxylate content hydrophilic influences global morphology. The resulting micelles are degradable aqueous environments can transform into spherical structures when combined conventional surfactants. As proof concept, small-molecule cargos were successfully loaded released from mixed demand. platform offers versatile route to create functional, stimulus-responsive surfactants tunable assembly, degradation, controlled release capabilities.

Language: Английский

Prodrug-designed nanocarrier co-delivering chemotherapeutic and vascular disrupting agents with exceptionally high drug loading capacity DOI

Huicong Zhou,

Zhaofan Yang,

Guan-Yu Jin

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113628 - 113628

Published: March 1, 2025

Language: Английский

Citations

0
Reverse Block Sequence in Self-Immolative Poly(benzyl ether)-Based Amphiphiles for Tailoring End Groups and Self-Assembly Behavior DOI

Ji Woo Kim,

Tae-Il Kang,

Eunpyo Choi

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

This paper reports a modular design of self-immolative poly(benzyl ether) (PBE) amphiphiles that allows precise control over polymer chain structure, end-group placement, and degradation behavior. By tuning block sequences exposing reactive end groups, these undergo efficient head-to-tail depolymerization upon external stimuli. Structural variations in the monomers enable micelle formation with groups displayed on surface, while carboxylate content hydrophilic influences global morphology. The resulting micelles are degradable aqueous environments can transform into spherical structures when combined conventional surfactants. As proof concept, small-molecule cargos were successfully loaded released from mixed demand. platform offers versatile route to create functional, stimulus-responsive surfactants tunable assembly, degradation, controlled release capabilities.

Language: Английский

Citations

0