The Role of Vanadium in Metallodrugs Design and Its Interactive Profile with Protein Targets DOI Creative Commons
Otávio Augusto Chaves, Francisco Mainardi Martins, Carlos Serpa

et al.

Future Pharmacology, Journal Year: 2024, Volume and Issue: 4(4), P. 743 - 774

Published: Oct. 24, 2024

Metallodrugs represent a critical area of medicinal chemistry with the potential to address wide range diseases. Their design requires multidisciplinary approach, combining principles inorganic chemistry, pharmacology, and molecular biology create effective safe therapeutic agents. Vanadium, element fifth group first transition series (3d metals), has been already detected as crucial species in biological action some enzymes, e.g., nitrogenases chloroperoxidase; furthermore, vanadium-based compounds have recently described physiologically stable behavior, having anticancer, antidiabetic (insulin-mimicking), antiprotozoal, antibacterial, antiviral, inhibition neurodegenerative disease properties. Since binding metallodrugs serum albumin influences distribution, stability, toxicity (intended off-target interactions), overall pharmacological properties, biophysical characterization between is one hot topics pharmacology. Overall, since vanadium complexes offer new possibilities for novel metallodrugs, this review summarized up-to-date aspects, highlighting proteins main targets based on metal.

Language: Английский

The Role of Vanadium in Metallodrugs Design and Its Interactive Profile with Protein Targets DOI Creative Commons
Otávio Augusto Chaves, Francisco Mainardi Martins, Carlos Serpa

et al.

Future Pharmacology, Journal Year: 2024, Volume and Issue: 4(4), P. 743 - 774

Published: Oct. 24, 2024

Metallodrugs represent a critical area of medicinal chemistry with the potential to address wide range diseases. Their design requires multidisciplinary approach, combining principles inorganic chemistry, pharmacology, and molecular biology create effective safe therapeutic agents. Vanadium, element fifth group first transition series (3d metals), has been already detected as crucial species in biological action some enzymes, e.g., nitrogenases chloroperoxidase; furthermore, vanadium-based compounds have recently described physiologically stable behavior, having anticancer, antidiabetic (insulin-mimicking), antiprotozoal, antibacterial, antiviral, inhibition neurodegenerative disease properties. Since binding metallodrugs serum albumin influences distribution, stability, toxicity (intended off-target interactions), overall pharmacological properties, biophysical characterization between is one hot topics pharmacology. Overall, since vanadium complexes offer new possibilities for novel metallodrugs, this review summarized up-to-date aspects, highlighting proteins main targets based on metal.

Language: Английский

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