Electrochemical Nickel-Catalyzed C(sp²)-H Functionalization of Tropones with Aldehydes

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 3184 - 3190

Published: Feb. 6, 2025

A direct electroreductive functionalization of tropones employing aldehydes as alkylating agents is reported. This C(sp2)-H process leverages the mediation electroactive nickel complexes, enabling a wide range both native and substituted (44 examples) to be alkylated selectively at α-position in high yields (up 90%). Combined electrochemical, spectroelectrochemical, computational analyses disclosed whole mechanistic pathway revealed key role played by reduced Ni complexes activating tropone core toward condensation with aldehydes.

Language: Английский

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The recyclable non-metal acid-catalyzed ammination of benzyl alcohol

Sustainable Chemistry and Pharmacy, Journal Year: 2025, Volume and Issue: 44, P. 101957 - 101957

Published: March 3, 2025

Language: Английский

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Catalytic Schmittel-Type [2+2] Cycloaddition of γ-Alkynyl Diazoacetates with Terminal Alkynes for Accessing Cyclobuta[a]indenes

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Instead of the conventional [4+2] cycloaddition, a regioselective Schmittel-type [2+2] cycloaddition yne–allene esters, generated in situ from copper-catalyzed dediazotized coupling γ-alkynyl diazoacetates with terminal alkynes, is reported, enabling bicyclization process to produce diverse array C1-arylated cyclobuta[a]indenes moderate good yields. The protocol features wide functional group compatibility, mild reaction conditions, and experimental simplicity, holding significant potential for building new tricyclic cyclobutenes.

Language: Английский

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Quantitative insights into BIM- WWTPs projects: a PLS-SEM approach

Published: April 23, 2025

is to develop a quantitative model that identifies and analyzes the factors contributing delays in adoption of Building Information Modeling (BIM) design implementation water wastewater treatment plants (WWTPs). As critical infrastructure components, effective management WWTPs plays fundamental role bridging gap between execution, ultimately enhancing project efficiency. Despite significant advancements BIM technology its recognized importance recent years, underlying causes remain unclear, posing substantial barrier fully realizing benefits this sector. order create quantified model, systematic questionnaire survey was used gather primary empirical data from plant (WWTP) designers implementer s as well professionals construction The Partial Least Squares Structural Equation (PLS-SEM) approach then evaluate gathered data, Smart PLS software dependable strong statistical analysis tool. This method makes it possible pinpoint measure main WWTP projects. By offering first results provide useful guide for practitioners who manage coach teams implementing BIM. These can also be converted into series guidelines improve practical use projects, which will overall performance, coordination, execution

Language: Английский

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Triquinane Based Natural Products Via Cycloadditions and Metathesis

Published: Jan. 1, 2024

Language: Английский

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Tropone hydrazides in [10+2]‐hetero‐higher‐order cycloaddition for the synthesis of tetrahydropyridazine derivatives

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

Abstract [10+2]‐Hetero‐higher‐order cycloaddition between tropone hydrazides (acting as 10π‐components) and 3‐alkylidene oxindoles 2π‐components) has been established. Under Brønsted base catalysis the reaction proceeded in a fully peri‐ diastereoselective manner with stereochemical outcome governed mainly by electronic interactions. Following such strategy, series of structurally diverse tetrahydropyridazines were prepared 30–70% yields. Furthermore, potential obtained cycloadducts confirmed selected chemoselective transformations.

Language: Английский

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Strategic 1,9-Proton-Transfer-Driven Cycloaddition: Synthesis and Stereoselective Contraction of Nine-Membered Heterocycles

ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(21), P. 16105 - 16114

Published: Oct. 17, 2024

We introduce a phosphine-catalyzed cycloaddition involving unprecedented long-range intramolecular proton transfer, facilitating the synthesis of nine-membered heterocycles, which are privileged structures in natural products, as well potent pharmacophores. Experimental and computational studies revealed that enamide tether N-aromatic zwitterion directly enables regioselective transfer to proceed independently outer-sphere shuttling. This understanding selective has led improved efficiency regioselectivity desired 1,9-proton reaction under anhydrous conditions, thereby advancing development higher-order reactions. Further stereoselective contraction synthesized cyclic compounds using 3-aza-Cope rearrangement demonstrates synthetic versatility our approach. The findings this study not only advance general mechanism but also broaden its practical utility various chemical fields.

Language: Английский

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Triquinane Based Natural Products via Cycloadditions and Metathesis

Tetrahedron Chem, Journal Year: 2024, Volume and Issue: unknown, P. 100103 - 100103

Published: Oct. 1, 2024

Language: Английский

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Catalyst-Controlled Switchable Formal Retro-Büchner reaction for the Divergent Synthesis of Benzo[b]azepines and 1, 3-Conjugated Dienes

Tetrahedron, Journal Year: 2024, Volume and Issue: 169, P. 134378 - 134378

Published: Nov. 13, 2024

Language: Английский

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