NBS-mediated C(sp³)–H amidation of N,N-dimethylamides with N-acyloxyamides

Chemical Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Efficient synthesis of methylenebisamides was achieved by NBS-mediated amidation C(sp 3 )–H bonds adjacent to the nitrogen in N , -dimethylamides with -acyloxyamides.

Language: Английский

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Nitrene-mediated Aminative N–N–N Coupling: Facile Access to Triazene 1-Oxides

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A nitrene-mediated aminative N–N–N coupling enables direct triazene 1-oxide synthesis via an aminonitrene–nitrosoarene pathway.

Language: Английский

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Visible-Light-Promoted α-C(sp³)–H Amidation of Cyclic Ethers under Redox-Neutral Conditions

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

Reported herein is a visible-light-promoted strategy for the α-C(sp3)–H amidation of cyclic ethers using N-acyloxyamide as an oxidative amidating reagent. This transformation provides straightforward approach to various α-amidated under metal- and additive-free conditions. The synthetic utility products was demonstrated through facile transformations, including reduction, allylation, acylation, sulfonamidation, gram-scale reactions. Preliminary mechanistic studies suggest radical/radical cross-coupling process, with C(sp3)–H bond cleavage identified rate-determining step.

Language: Английский

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Recent Advances in the Synthetic Applications of Nitrosoarene Chemistry

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

This review covers reactions involving nitrosoarenes over the last decade, including cyclization, with attacks at oxygen or nitrogen terminus, dimerization, rearrangement, coordination, and other significant reactions.

Language: Английский

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