Efficient Synthesis of Bis(indolyl)methane Derivatives on Heterogeneous Ga‐MCM‐41‐SO₃H Catalyst under Mild Conditions

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(41)

Published: Oct. 28, 2024

Abstract We are reporting a convenient method for the synthesis of bis(indolyl)methane derivatives from relatively cheap and commercially available chemicals such as indoles aldehydes in one‐pot procedure using Ga‐MCM‐41‐SO 3 H heterogeneous catalyst. Notably, use this catalyst has resulted high yield products (up to 98 %) under mild conditions, was found be stable reusable, retaining its highly catalytic activity even after five runs. Interestingly, two alkaloids Arsindoline A Turbomycine B were successfully synthesized employment These findings suggest that could promising alternative traditional acid homogeneous catalysts derivatives, offering several advantages including ease separation reuse, stability, low toxicity.

Language: Английский

Modular Synthesis of C₂‐Symmetric Chiral TPy‐BPI Pincer Ligands and Application in Asymmetric Ni(II)‐Catalysed Friedel‐Crafts Alkylation

Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Comprehensive Summary Terpyridine ligands have been applied as a class of unique due to their rich coordination chemistry in the catalysis. Herein, we developed new C 2 ‐symmetric chiral terpyridine‐pyrroloimidazolone (TPy‐BPI). Their catalytic activity was evaluated asymmetric Friedel‐Crafts alkylation indoles with 2,3‐dioxopyrrolidines. Excellent yields (up 92%) and high enantioselectivities 97% ee) are obtained for wide range substrates under mild conditions. In addition 2,3‐dioxopyrrolidines, β , γ ‐unsaturated α ‐ketoesters were also compatible Ni(OTf) ‐TPy‐BPI ligand L1 ‐catalyzed reaction. Control experiments, single crystal structure two TPy‐BPI ‐Ni(OTf) complexes, DFT calculations revealed origins enantioselectivity. To best our knowledge, work is first report showing that terpyridine framework contained only nitrogen atoms coordinating metal, additional pyridine unit acted stereodirecting element, which different from previously reported containing all three metal.

Language: Английский

Asymmetric Synthesis of Optically Active Pyrazolidines or Pyrazoline Derivatives via Ni(II)-Bipyridine-N,N′-dioxide Complexes

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Easily obtainable and efficient chiral

Language: Английский