Palladium-Catalyzed Domino Carboetherification Reactions: Synthesis of Bis-Heterocycles Bearing Isoxazoline and Methyleneindole Motifs DOI

Feifei Jin,

Qing Wu,

Shuaijie Wu

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

A novel and highly efficient Pd-catalyzed approach for the synthesis of bis-heterocycles featuring both isoxazoline methyleneindole motifs is demonstrated. The in situ formation vinyl Pd(II) species through an alkyne-tethered carbamoyl chloride cyclization crucial, innovative carboetherification β,γ-unsaturated oximes with has been developed. This method not only operationally straightforward but also exhibits a broad substrate scope excellent functional group tolerance.

Language: Английский

Enantioselective synthesis of isoxazolines bearing allenes by palladium-catalyzed carboetherification of β,γ-unsaturated ketoximes with propargylic acetates DOI

Feifei Jin,

Cangzhu Hu,

Shuaijie Wu

et al.

Organic Chemistry Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Enantioselective synthesis of isoxazolines bearing allenes by palladium catalyzed carboetherification alkenyl oximes with propargylic acetates. DFT calculations carried out to disclose the detailed mechanism and origins enantioselectivity.

Language: Английский

Citations

1
Transient Directing Group-Assisted Palladium-Catalyzed C4-Alkynylation of Indoles DOI

Shuqi Guo,

Huanfeng Jiang,

Shaorong Yang

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Pd-catalyzed C4-selective alkynylation of indoles was established by employing glycine as a transient directing group. This reaction exhibits high regioselectivity with the tolerance wide scope functional groups to afford diverse alkynylated in moderate good yields. Moreover, readily accessible scale-up synthesis and further decorations achieve multifunctionalized demonstrate synthetic potential this protocol.

Language: Английский

Citations

0
Palladium-Catalyzed Domino Carboetherification Reactions: Synthesis of Bis-Heterocycles Bearing Isoxazoline and Methyleneindole Motifs DOI

Feifei Jin,

Qing Wu,

Shuaijie Wu

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

A novel and highly efficient Pd-catalyzed approach for the synthesis of bis-heterocycles featuring both isoxazoline methyleneindole motifs is demonstrated. The in situ formation vinyl Pd(II) species through an alkyne-tethered carbamoyl chloride cyclization crucial, innovative carboetherification β,γ-unsaturated oximes with has been developed. This method not only operationally straightforward but also exhibits a broad substrate scope excellent functional group tolerance.

Language: Английский

Citations

0