Catalytic Enantioselective Functionalization of Maleimides: An Update DOI Creative Commons
Muriel Amatore, Damien Bonne,

Thierry Constantieux

et al.

Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: 42(24), P. 3605 - 3622

Published: Nov. 13, 2024

Comprehensive Summary Maleimide derivatives are well‐established reactive intermediates also found in natural products, synthetic pharmaceuticals and functional polymers. Their specific reactivity widespread applications the field of bioconjugation allowed for development highly selective functionalizations based on simple additions cycloadditions with possible control central C–N axial chirality. These multisite‐reactive scaffolds have aroused a long‐standing interest throughout scientific community more particularly as powerful electrophilic partners recently nucleophilic some transformations. The persistent these easily accessible platforms over last decade has enabled new enantioselective transformations major advancements this presented review. Key Scientists

Language: Английский

Enantioselective synthesis of molecules with multiple stereogenic elements DOI Creative Commons
Arthur Gaucherand, Expédite Yen‐Pon,

Antoine Domain

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(22), P. 11165 - 11206

Published: Jan. 1, 2024

This review explores the fascinating world of molecules featuring multiple stereogenic elements, unraveling different strategies designed over years for their enantioselective synthesis.

Language: Английский

Citations

15
Synthesis of Chiral Heterocycles Through Enantioselective Silver‐Catalyzed Transformations DOI Open Access

Hélène Pellissier

European Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Abstract This review collects the recent developments in synthesis of chiral heterocycles through enantioselective silver‐catalyzed transformations published since 2018. It demonstrates power silver catalysts as special mild Lewis acids to provide an impressive diversity reaction pathways, such 1,3‐dipolar cycloadditions, various types cyclizations, along with a wide variety more complex domino/tandem reactions, allowing many novel heterocyclic products be achieved high enantioselectivities.

Language: Английский

Citations

1
New pyrrolo[3,4-d] isoxazolidines hbrid with furan as multi-target antitumor agents and multi-target enzyme inhibitors: Synthesis and in silico study DOI
Awаd I. Said, Wafaa A Ewes, Abdelrahman Hamdi

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108377 - 108377

Published: March 1, 2025

Language: Английский

Citations

1
Recent Developments in Enantioselective Silver-Catalyzed Transformations DOI

Hélène Pellissier

Organic Preparations and Procedures International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 95

Published: April 11, 2025

Language: Английский

Citations

0
Recent Advances in Catalytic Atroposelective Synthesis of Axially Chiral Quinazolinones DOI Open Access
Yilin Liu, Jiaoxue Wang, Yanli Yin

et al.

Catalysts, Journal Year: 2025, Volume and Issue: 15(5), P. 426 - 426

Published: April 27, 2025

Quinazolinones, a class of nitrogen-containing heterocyclic compounds, occupy crucial position in medicinal chemistry and materials science due to their significant application potential. In recent years, the catalytic asymmetric synthesis axially chiral quinazolinones has emerged as prominent research area, driven by prospective applications development bioactive molecules, design ligands, fabrication functional materials. This review comprehensively summarizes advancements quinazolinones, with particular focus on construction strategies for three major structural types: C–N axis, N–N C–C axis. Key synthetic methodologies, including atroposelective halogenation, kinetic resolution, condensation–oxidation, photoredox deracemization, are discussed detail. addition, provides an in-depth analysis various systems, such peptide catalysis, enzymatic metal phosphoric acid others. Despite substantial progress made thus far, several challenges remain, expansion substrate scope, enhanced control over stereoselectivity, further exploration practical applications, drug discovery catalysis. These insights expected guide future towards novel strategies, diversification variants, comprehensive understanding biological activities functions. Ultimately, this will foster continued growth evolution rapidly advancing field.

Language: Английский

Citations

0
Catalytic Enantioselective Functionalization of Maleimides: An Update DOI Creative Commons
Muriel Amatore, Damien Bonne,

Thierry Constantieux

et al.

Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: 42(24), P. 3605 - 3622

Published: Nov. 13, 2024

Comprehensive Summary Maleimide derivatives are well‐established reactive intermediates also found in natural products, synthetic pharmaceuticals and functional polymers. Their specific reactivity widespread applications the field of bioconjugation allowed for development highly selective functionalizations based on simple additions cycloadditions with possible control central C–N axial chirality. These multisite‐reactive scaffolds have aroused a long‐standing interest throughout scientific community more particularly as powerful electrophilic partners recently nucleophilic some transformations. The persistent these easily accessible platforms over last decade has enabled new enantioselective transformations major advancements this presented review. Key Scientists

Language: Английский

Citations

2