Chemical Communications,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
The
synthesis
of
N-heterocycles
has
received
extensive
attention
from
scientists
considering
their
important
role
in
organic
synthesis,
pharmaceuticals,
and
materials
chemistry.
α-Amino
acids
(α-AAs),
both
natural
non-natural,
are
structurally
diverse,
containing
basic
amino
groups,
acidic
carboxyl
various
side-chain
R
groups
a
single
molecule.
Given
structural
properties
wide
range
sources,
they
have
undoubtedly
become
suitable
synthetic
building
blocks
for
synthesis.
However,
conventional
transformations
(AAs)
focus
on
the
independently.
Conversions
these
two
prominent
functional
generally
do
not
affect
alpha
positions
branched
chains.
Over
past
decade,
with
application
iodine
(I
New Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
48(28), P. 12544 - 12552
Published: Jan. 1, 2024
Synthesis
of
tetrahydro
indole-2,4-diones
from
readily
available
β-enaminones
and
glyoxal
subsequent
I
2
/DMSO-mediated
oxidation/aromatization
indole-2,4-dione
to
produce
4-hydroxyisatin
derivatives.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 9, 2024
Abstract
Skeleton
editing
for
heteroarenes,
especially
pyrazoles,
is
challenging
and
remains
scarce
due
to
these
non-strained
aromatics
feature
inert
reactivities
therefore
relatively
inactive
perform
a
dearomatization/cleavage
sequence.
Herein,
we
disclose
cycloaddition-induced
scaffold
hopping
of
5-hydroxypyrazoles
access
pyrazolopyridopyridazin-6-one
skeleton
in
single-operation
protocol.
By
converting
five-membered
azaarene
into
five-unit
spine
6/6
fused-bicyclics,
this
work
has
unlocked
new
ring-opening
reactivity
pyrrole
core
that
involves
formal
C
=
N
bond
cleavage
while
retaining
the
highly
reactive
N-N
resulting
product.
A
[4
+
2]
cycloaddition
temporary
dearomatized
5-hydroxypyrrole
with
anin
situgenerated
aza-1,3-diene
follow-up
oxidative
C-N
accounted
domino
pathway.
library
pyrazolopyridopyridazin-6-one,
which
are
medicinally
relevant
nitrogen-atom-rich
tricyclics,
was
obtained
efficiently
from
readily
available
materials.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(21), P. 4399 - 4403
Published: July 16, 2024
Abstract
A
multicomponent
cascade
cyclization
reaction
using
aryl
methyl
ketones,
amines,
and
enaminamide
reagents
to
construct
3‐hydroxy‐1
H
‐pyrrolo[3,4‐
b
]quinolin‐1‐one
skeleton
with
good
substrate
compatibility
(50
examples)
has
been
reported.
The
one‐pot,
metal‐free
process
formed
two
C−C
bonds,
C−N
a
tetrasubstituted
carbon
stereocenter
containing
hydroxyl
group.
enabled
modified
transformation
of
drug
molecules
derivatization
products.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(72), P. 9781 - 9784
Published: Jan. 1, 2024
An
oxidant-controlled
divergent
synthesis
of
a
pyrrolidone
fused
pyrimido[1,2-
b
]indazole
skeleton
was
developed
through
selective
cyclization
an
in
situ
generated
enone
intermediate
and
1
H
-indazol-3-amine.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(36), P. 7478 - 7484
Published: Jan. 1, 2024
A
metal-free,
iodine-catalyzed
protocol
for
the
synthesis
of
biologically
significant
5-aroyl
1,2,4-oxadiazole
scaffolds
has
been
developed
using
aryl
methyl
ketones
and
amidoximes.
Abstract
An
iodine‐mediated
C=C
double
bond‐forming
reaction
has
been
established
to
access
various
fused
quinolinone
derivatives
under
transition
metal‐free
conditions.
The
present
is
also
applicable
the
synthesis
of
quinolinium
frameworks
from
corresponding
precursors
and
can
be
conducted
on
a
gram
scale.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
The
synthesis
of
N-heterocycles
has
received
extensive
attention
from
scientists
considering
their
important
role
in
organic
synthesis,
pharmaceuticals,
and
materials
chemistry.
α-Amino
acids
(α-AAs),
both
natural
non-natural,
are
structurally
diverse,
containing
basic
amino
groups,
acidic
carboxyl
various
side-chain
R
groups
a
single
molecule.
Given
structural
properties
wide
range
sources,
they
have
undoubtedly
become
suitable
synthetic
building
blocks
for
synthesis.
However,
conventional
transformations
(AAs)
focus
on
the
independently.
Conversions
these
two
prominent
functional
generally
do
not
affect
alpha
positions
branched
chains.
Over
past
decade,
with
application
iodine
(I
