Convergent Assembly of 1,4-Benzothiazide Spiroindolinones via [4 + 2] Spiroannulation Under Open-Air Conditions DOI
Wenxiang Hu,

Kai-Heng Yu,

Feng‐Cheng Jia

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(22), P. 16531 - 16541

Published: Nov. 4, 2024

This report discloses a transition-metal-free [4 + 2] spirocyclization of isatin-derived β-silylcarbinols and 2-aminobenzenethiols, providing facile approach to 1,4-benzothiazide spiroindolinones in decent yields. Control experiments indicate that 3-methylene oxindoles disulfides are key intermediates this tandem reaction. Moreover, the resulting products can be facilely converted into pharmaceutically significant sulfone sulfoxide scaffolds, which further demonstrates potential utility protocol.

Language: Английский

Base-Promoted Tandem Cyclization of 2-(Indol-3-yl)naphthoquinones with Benzamidines toward Polysubstituted Pyrimido[4,5-b]indoles DOI
Bin Tan, Kai Hu, Chao Zhang

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

A novel and unique approach for the construction of polysubstituted pyrimido[4,5-

Language: Английский

Citations

0
Convergent Assembly of 1,4-Benzothiazide Spiroindolinones via [4 + 2] Spiroannulation Under Open-Air Conditions DOI
Wenxiang Hu,

Kai-Heng Yu,

Feng‐Cheng Jia

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(22), P. 16531 - 16541

Published: Nov. 4, 2024

This report discloses a transition-metal-free [4 + 2] spirocyclization of isatin-derived β-silylcarbinols and 2-aminobenzenethiols, providing facile approach to 1,4-benzothiazide spiroindolinones in decent yields. Control experiments indicate that 3-methylene oxindoles disulfides are key intermediates this tandem reaction. Moreover, the resulting products can be facilely converted into pharmaceutically significant sulfone sulfoxide scaffolds, which further demonstrates potential utility protocol.

Language: Английский

Citations

0