Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 19, 2024
A
method
was
found
to
construct
sulfur-containing
five-
and
six-membered
heterocyclic
alkyl
sulfonyl
compounds
by
using
visible
light
free
radicals
activated
and/or
generated
EDA
complexes/homolytic
cleavage
as
initiators
stimulate
the
relay
reaction
of
alkynes/alkynones.
This
puts
forward
a
new
strategy
initiate
sulfonation
alkynes/alkynones
with
only
catalytic
amount
initiator.
generating
initiator
complex
activation/homolytic
provides
idea
for
following
substances
that
must
be
excited.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
In
this
study,
a
novel
approach
that
combines
photoinduced
electron
transfer
(ET)
with
hydrogen
atom
(HAT)
has
been
introduced
for
the
selective
β-C(sp3)–H
pyridination
of
carbonyl
compounds.
This
method
is
notable
its
absence
transition
metals
and
ability
to
function
under
benign
reaction
conditions,
resulting
in
range
pyridinated
derivatives
consistently
moderate
good
yields.
The
significance
technique
further
underscored
by
potential
late-stage
functionalization
pharmaceutically
significant
molecules.
Mechanistic
investigations
confirmed
proceeds
via
radical-mediated
pathway.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
90(4), P. 1683 - 1696
Published: Jan. 17, 2025
In
the
vanguard
of
sustainable
chemistry,
pursuit
efficient
pathways
for
synthesis
alkyl
bicyclo[1.1.1]pentane-heteroaryls
has
captured
attention
scientific
vanguard.
We
herein
report
a
groundbreaking
and
eco-conscious
multicomponent
coupling
reaction
that
paves
way
alkylation
heteroarylation
[1.1.1]propellane,
process
uniquely
enabled
by
photochemical
prowess
an
electron
donor–acceptor
(EDA)
complex.
This
method
is
distinguished
its
minimalist
yet
powerful
approach:
devoid
transition
metals,
additives,
photosensitizers.
Its
universality
further
exemplified
seamless
compatibility
broad
spectrum
halides
heteroarenes
under
standardized
conditions,
heralding
new
era
synthetic
versatility.
The
method's
practicality
underscored
capacity
late-stage
modification
pharmaceuticals,
offering
transformative
tool
enhancement
existing
drug
molecules.
Moreover,
facile
derivatization
synthesized
products
underscores
adaptability
potential
diverse
applications.
Our
mechanistic
studies
have
elucidated
underlying
radical-relay
pathway,
pinpointing
pivotal
role
EDA
complex
in
initiating
transformation.
discovery
not
only
enriches
our
fundamental
understanding
but
also
opens
avenues
strategic
optimization.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
27(10), P. 2526 - 2531
Published: March 5, 2025
Herein,
we
introduce
an
efficient
and
straightforward
strategy
for
the
selective
C-H
esterification
alkylation
of
quinoxalin-2(1H)-ones
with
aldehydes.
A
key
feature
our
study
is
ability
to
perform
both
using
different
types
The
reaction
system
highly
compatible
a
range
aldehydes,
yielding
C3-esterified
C3-alkylated
products
in
moderate-to-good
yields.
applicability
this
approach
further
enhanced
by
its
scalability
through
continuous-flow
synthesis,
late-stage
modification
significant
molecules,
product
derivatization.
Our
mechanistic
investigations
reveal
radical
relay
mechanism,
triggered
hydrogen
atom
transfer
process.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(33), P. 7060 - 7065
Published: Aug. 13, 2024
Bicyclo[1.1.1]pentane
(BCP)
heteroaryls
make
up
an
important
class
of
BCP
derivatives
in
drug
discovery.
Herein,
we
report
the
visible-light-mediated
synthesis
cyanoisopropyl
BCP-heteroaryls
motifs
from
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
This
study
describes
a
pioneering
visible-light-induced
phosphine-catalyzed
halogen-atom
transfer
(XAT)
strategy
that
heralds
new
era
in
the
difunctionalization
of
[1.1.1]propellane.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Herein,
a
N-phenylphenothiazine-based
hyper-cross-linked
polymer
(PTH-HCP)
was
finely
designed
and
constructed,
which
serves
as
metal-free
heterogeneous
photocatalyst
for
organic
transformations.
Characterization
experiments
have
shown
that
this
demonstrates
outstanding
stability,
extensive
surface
area,
exceptional
photoelectric
response
properties.
Moreover,
PTH-HCP
showed
good
catalytic
efficiency
recyclability
in
the
photochemically
driven
difluoromethylation/cyclization
reactions.
This
work
provides
strategy
design
construction
of
photocatalysts
offers
support
their
broad
prospects
synthetic
applications.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 11, 2025
An
EnT-mediated
C3-N-heteroarylation
of
2-aryl
quinoxalines
via
decarboxylative
radical-radical
cross-coupling
(C(sp2)-C(sp2))
with
oxime
esters
is
presented.
Upon
photoactivation,
the
triplet
energy
photocatalyst
transferred
to
both
reacting
partners
(oxime
ester
and
2-phenylquinoxaline).
The
excited
undergoes
fragmentation
a
C-centered
N-heteroaryl
radical
an
N-centered
imine
radical.
former
attacks
C3
site
quinoxaline
diradical,
while
latter
acts
as
hydrogen
atom
abstractor
(HAA).
Computational
studies
revealed
that
C-C
bond
formation
heteroaryl
energetically
more
favorable
than
C-N
formation.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(46), P. 9973 - 9977
Published: Nov. 14, 2024
Herein,
we
disclose
a
readily
available
phenothiazine
derivative
as
an
organocatalyst,
which
upon
excitation
with
371
nm
light
acquires
strongly
reducing
power
and
serves
to
induce
the
radical
cascade
difluoromethylation/cyclization
reaction
of
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 25, 2024
Herein,
the
first
example
of
self-catalyzed
sono-photoinduced
carbon-carbon
bond
formation
was
described.
Combining
advantages
phototriggered
self-catalysis
and
ultrasonic
catalysis,
a
wide
range
3-arylquinoxalin-2(1
