Visible-Light-Induced C–H Alkylation of 1,2,4-Triazine-3,5(2H,4H)-diones via Infrequent 1,2-Hydrogen-Atom Transfer DOI
Mi Wang, Yangyang Wang, Jie Wang

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

1,2,4-Triazine-3,5(2H,4H)-diones are widely present in various drug molecules and bioactive molecules. A visible-light-driven C-H alkylation of 1,2,4-triazine-3,5(2H,4H)-diones via 1,2-hydrogen-atom transfer (1,2-HAT) amide radicals is first reported, providing an environmentally friendly sustainable pathway to enrich the structural functional diversity 1,2,4-triazine-3,5(2H,4H)-diones. This novel protocol characterized by mild metal-free reaction conditions, operationally simple method, good group tolerance. To our delight, other heterocycles, such as isoquinoline coumarin, also undergo reactions construct C(sp2)-C(sp3) bonds infrequent 1,2-HAT under current conditions.

Language: Английский

Visible-Light-Induced C–H Alkylation of 1,2,4-Triazine-3,5(2H,4H)-diones via Infrequent 1,2-Hydrogen-Atom Transfer DOI
Mi Wang, Yangyang Wang, Jie Wang

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

1,2,4-Triazine-3,5(2H,4H)-diones are widely present in various drug molecules and bioactive molecules. A visible-light-driven C-H alkylation of 1,2,4-triazine-3,5(2H,4H)-diones via 1,2-hydrogen-atom transfer (1,2-HAT) amide radicals is first reported, providing an environmentally friendly sustainable pathway to enrich the structural functional diversity 1,2,4-triazine-3,5(2H,4H)-diones. This novel protocol characterized by mild metal-free reaction conditions, operationally simple method, good group tolerance. To our delight, other heterocycles, such as isoquinoline coumarin, also undergo reactions construct C(sp2)-C(sp3) bonds infrequent 1,2-HAT under current conditions.

Language: Английский

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