ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(40)

Published: Oct. 1, 2024

Abstract In this study, we report a Rh(I)/dppf catalytic system that can tune the regioselectivity of methylenecyclobutanes. Under optimal reaction conditions, series 1,3‐disubstituted cyclobutanes were prepared in high yields (up to 95%) with excellent (>20:1 r.r.). Scale‐up synthesis cyclobutane product at low catalyst loading (2 mol%) demonstrates robustness dppf‐controlled hydroacylation.

Language: Английский