The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 90(4), P. 1656 - 1662

Published: Jan. 21, 2025

We report a photoredox-catalyzed three-component sulfonaminoalkynylation of alkenes with N-aminopyridine salts and potassium alkynyltrifluoroborate salts. This aminoalkylation reaction underwent radial/polar crossover mechanism, which was distinguished from the previous reports. A variety β-alkynylated sulfonamides were obtained in moderate to excellent yields. The versatility this method further evidenced by its successful application modifying biological molecules advanced stages development.

Language: Английский