Metal–organic framework MIL-101(Fe) functionalized with folic acid as a multifunctional nanocarrier for targeted chemotherapy–photodynamic therapy

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A novel folic acid-conjugated, iron-based metal framework MIL-101 (Fe) MOF loaded with 1,8-acridinediones (DO8) was developed for targeted photodynamic therapy (PDT).

Language: Английский

Cancer metastasis: molecular mechanisms and therapeutic interventions

Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)

Published: April 7, 2025

Abstract The metastatic cascade is a complicated process where cancer cells travel across multiple organs distant from their primary site of onset. Despite the wide acceptance ‘seed and soil’ theory, mechanisms driving metastasis organotropism remain mystery. Using breast different subtypes as disease model, we characterized ‘metastatic profile cells’ ‘redox status organ microenvironment’ determinants organotropism. Mechanically, identified positive correlation between metabolic plasticity stemness, proposed oxidative stress selection power succeeding cascade. Therapeutically, use pro-oxidative therapeutics in ablating taking advantages this fragile moment during metastasis. We comprehensively reviewed current strategies for treating cancers that cover first line chemo- radio-therapies, approaches relying on naturally existing including magnetic field, electric light sound, nanoparticle-based anti-cancer composites obtained through artificial design, well cold atmospheric plasma an innovative multi-modal modality. discussed possible combinations with oncology prior to forecast future research directions. This paper fundamental mechanics intervention accordingly. Insights provided here may offer clues design solutions open new paradigm treatment.

Language: Английский

Slowing Down the “Magic Bullet”: Encapsulation of Imatinib in Fe-MOF for Cardiotoxicity Reduction and Improvement in Anticancer Activity

Molecules, Journal Year: 2024, Volume and Issue: 29(16), P. 3818 - 3818

Published: Aug. 12, 2024

Imatinib, a small molecule kinase inhibitor, is used as cancer growth blocker. However, one of its most serious side effects congestive cardiac failure. Reducing drug toxicity may be achieved through the use delivery systems. Biocompatible metal-organic framework (MOF) materials, namely FeMIL-100 and FeMIL-101-NH

Language: Английский