Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 207 - 207
Published: Feb. 18, 2025
The rapid rise of antibiotic resistance has become a global health crisis, necessitating the development innovative strategies to combat multidrug-resistant (MDR) pathogens. Nanomaterials have emerged as promising tools in this fight, offering unique physicochemical properties that enhance efficacy, overcome mechanisms, and provide alternative therapeutic approaches. This review explores diverse nanomaterial-based used resistance, focusing on their mechanisms action practical applications. such metal nanoparticles, carbon-based nanomaterials, polymeric nanostructures exhibit antibacterial through various pathways, including generation reactive oxygen species (ROS), disruption bacterial membranes, enhancement delivery. Additionally, ability nanomaterials bypass traditional biofilm formation efflux pumps, been demonstrated numerous studies. also discusses synergistic effects observed when are combined with conventional antibiotics, leading increased susceptibility reduced required dosages. By highlighting recent advancements clinical applications nanomaterial-antibiotic combinations, paper provides comprehensive overview how reshaping future therapies. Future research directions challenges, toxicity scalability, addressed guide safer, more effective treatments.
Language: Английский
Citations
3
Infection and Drug Resistance, Journal Year: 2025, Volume and Issue: Volume 18, P. 1007 - 1033
Published: Feb. 1, 2025
The increasing incidence of antibiotic resistance in Staphylococcus aureus (S. aureus) poses a substantial threat to global public health. In recent decades, the evolution bacteria and misuse antibiotics have led progressive development drug S. aureus, resulting worldwide rise methicillin-resistant (MRSA) infection rates. Understanding molecular mechanisms underlying staphylococcal resistance, treatments for infections, efficacy nanomaterials addressing multi-drug is crucial. This review explores mechanisms, which include limiting uptake, target modification, inactivation through production degrading enzymes, active efflux drugs. It also examines current therapeutic strategies, such as combination therapy, phage monoclonal antibody nanoparticle with particular emphasis on role silver-based nanomaterials. Nanoparticles possess ability overcome offering novel avenue management drug-resistant bacteria. demonstrated potent antibacterial activity against various including cell membrane disruption, generation reactive oxygen species (ROS), inhibition essential cellular processes. highlights need further research optimize design, enhance their potency, ensure biocompatibility biodegradability. ultimately concludes by emphasizing importance multifaceted approach treatment, new antibiotics, investment stewardship programs prevent misuse, exploration natural compounds bacteriocins potential antimicrobial agents.
Language: Английский
Citations
1
Cureus, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
The increasing prevalence of bacterial resistance to conventional antimicrobial agents and nanoparticles (NPs) has become a critical global health challenge. This systematic review aimed evaluate strategies for overcoming by synthesizing evidence on nanoparticle composition, functionalization, targeted mechanisms. A comprehensive literature search studies published between 2000 2025 was conducted, focusing experimental designs assessing efficacy, biofilm disruption, efflux pump inhibition. reviewed highlighted advanced formulations, including silver-cyanographene conjugates, lanthanum-functionalized graphene oxide, carbon nanogels, which demonstrated enhanced efficacy against resistant strains. Key findings emphasized the role surface size modulation, combination therapies in mitigating resistance. Functionalized effectively disrupted matrices, inhibited pumps, intracellular penetration, reducing survival rates. Despite promising results, challenges remain, variability limited scalability, long-term ecological impacts. underscores potential innovative combat emphasizes need standardized protocols clinical translation.
Language: Английский
Citations
0
RSC Advances, Journal Year: 2025, Volume and Issue: 15(7), P. 5639 - 5647
Published: Jan. 1, 2025
Li doping enhanced the ability of nano-MgO to adsorb oxygen and generate ROS, further improving its antibacterial performance.
Language: Английский
Citations
0
The Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 100307 - 100307
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113666 - 113666
Published: March 1, 2025
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0