RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(15), P. 11675 - 11687
Published: Jan. 1, 2025
We
developed
a
glutathione
(GSH)
responsive
nanoplatform
for
the
co-delivery
of
sorafenib
(Sor)
and
brusatol
(Bru).
This
enhanced
Bru’s
efficacy
increased
Sor’s
sensitivity.
innovative
approach
effectiveness
in
hepatocellular
carcinoma
(HCC)
treatment.
Gels,
Journal Year:
2025,
Volume and Issue:
11(4), P. 293 - 293
Published: April 15, 2025
As
an
intelligent
polymer
material,
pH-sensitive
hydrogels
exhibit
the
capability
to
dynamically
sense
alterations
in
ambient
pH
levels
and
subsequently
initiate
corresponding
physical
or
chemical
responses,
including
swelling,
contraction,
degradation,
ion
exchange.
Given
significant
variations
inherent
human
pathophysiological
microenvironments,
particularly
tumor
tissues,
inflammatory
lesions,
gastrointestinal
system,
these
smart
materials
demonstrate
remarkable
application
potential
across
diverse
domains
such
as
targeted
drug
delivery
systems,
regenerative
medicine
engineering,
biosensing,
disease
diagnostics.
Recent
breakthroughs
nanotechnology
precision
have
substantially
propelled
advancements
design
of
pH-responsive
hydrogels.
This
review
systematically
elaborates
on
current
research
progress
future
challenges
regarding
biomedical
applications,
with
particular
emphasis
their
stimulus–response
mechanisms,
fabrication
methodologies,
multifunctional
integration
strategies,
scenarios.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 21, 2025
Abstract
Cancer
vaccines
hold
promise
for
tumor
immunotherapy,
with
their
success
hinging
on
effective
systems
to
boost
anti‐tumor
immunity.
Biological
membranes
are
not
only
a
delivery
vehicle
but
also
source
of
antigens
and
adjuvants,
garnering
growing
interest
in
vaccine
research.
This
review
starts
an
introduction
the
composition
mechanisms
cancer
describes
sources,
advantages/disadvantages,
engineering
strategies,
applications
these
membrane‐based
platforms
development.
offers
critical
analysis
discusses
further
direction
platform
view
clinical
translation
immunotherapy.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(21), P. 1757 - 1757
Published: Oct. 31, 2024
The
application
of
nanomaterials
in
tumor
therapy
is
increasingly
widespread,
offering
more
possibilities
for
enhanced
therapy.
However,
the
unclear
biological
distribution
and
metabolism
may
lead
to
immune
rejection
or
inflammatory
reactions,
posing
numerous
challenges
their
clinical
translation.
rich
diversity
multifaceted
functions
blood
cells
offer
promising
avenues
enhancing
nanoparticles
cancer
Blood
cell
membranes,
being
made
naturally
found
components
body,
exhibit
significant
biocompatibility,
which
can
reduce
body’s
response,
extend
drug’s
residence
time
bloodstream,
enhance
its
bioavailability.
Integrating
membranes
with
enhances
by
improving
targeted
delivery,
prolonging
circulation
time,
evading
responses.
This
review
summarizes
recent
advancements
membrane-coated
antitumor
therapy,
a
particular
focus
on
use
photodynamic
photothermal
treatments.
Additionally,
it
explores
potential
synergistic
effects
when
combined
other
therapeutic
modalities.
Redox Biology,
Journal Year:
2024,
Volume and Issue:
79, P. 103452 - 103452
Published: Dec. 3, 2024
Despite
advances
in
multimodal
therapy
approaches
such
as
resection,
chemotherapy
and
radiotherapy,
the
overall
survival
of
patients
with
grade
4
glioblastoma
(GBM)
remains
extremely
poor
(average
time
<2
years).
Altered
lipid
metabolism,
which
increases
fatty
acid
synthesis
thereby
contributes
to
radioresistance
GBM,
is
a
hallmark
cancer.
Therefore,
we
explored
radiosensitizing
effect
clinically
approved,
lipid-lowering
drug
fenofibrate
(FF)
different
GBM
cell
lines
(U87,
LN18).
Interestingly,
FF
(50
μM)
significantly
radiosensitizes
U87
cells
by
inducing
DNA
double-strand
breaks
through
oxidative
stress
impairing
mitochondrial
membrane
integrity,
but
radioprotects
LN18
reducing
production
reactive
oxygen
species
(ROS)
stabilizing
potential.
A
comparative
protein
analysis
revealed
striking
differences
two
lines:
exhibited
higher
expression
density
(FA)
cluster
transporter
CD36
than
cells,
glycerol-3-phosphate
acyltransferase
(GPAT4)
supports
large
droplets
(LDs),
lower
diacylglycerol
O-acyltransferase
1
(DGAT1)
regulates
formation
small
LDs.
Consequently,
LDs
are
predominantly
found
whereas
cells.
After
combined
treatment
irradiation,
number
increased
radioresistant
decreased
radiosensitive
The
radioprotective
could
be
associated
presence
LDs,
act
sink
for
lipophilic
FF.
To
prevent
uptake
ameliorate
its
function
radiosensitizer,
was
encapsulated
biomimetic
extracellular
vesicles
(CmEVs)
alter
intracellular
trafficking
drug.
In
contrast
free
drug,
CmEV-encapsulated
enriched
lysosomal
compartment,
causing
necrosis
integrity.
Since
stability
plasma
membranes
maintained
stress-inducible
heat
shock
70
(Hsp70)
has
strong
affinity
tumor-specific
glycosphingolipids,
occurs
having
Hsp70
summary,
our
findings
indicate
that
metabolism
tumor
can
affect
capacity
when
encountered
either
or
loaded
vesicles.
