Application of Inorganic Carrier‐Loaded Chiral Catalysts in Asymmetric Catalysis

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 1, 2025

Abstract Chiral substances play a pivotal role in numerous contemporary fields, and their synthesis heavily relies on chiral catalysts. However, traditional homogeneous catalysts suffer from significant drawbacks, including difficulty separation products nonrecyclability. Immobilization of onto specific carrier offers an excellent solution to these challenges, significantly reducing the production cost. Consequently, this approach has emerged as inevitable trend development This review comprehensively summarizes representative examples asymmetric catalytic reactions using immobilized inorganic carriers over last decade, classifies them according type carrier, elucidates loading techniques recycling methods associated with carriers.

Language: Английский

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Synthesis of Homochiral N‐Heterocyclic Carbene‐Based Nanosheets for Enhanced Asymmetric Catalysis

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 19, 2024

Abstract Utilizing ultrathin 2D metal–organic framework nanosheets (2D MONs) as supports for incorporating chiral catalysts represents a highly promising avenue in the field of asymmetric catalysis. In this study, four pairs isostructural layers (MOLs) adorned with N ‐Heterocyclic carbene (NHC) groups are successfully synthesized. Notably, obtained bulky ( S )‐1‐Zn crystals can be readily delaminated into MONs consisting 1–2 through an ion intercalation‐assisted exfoliation process. Subsequent catalysis studies revealed that NHC sites effectively activated by proton sponge while maintaining structural integrity subsequent benzoin condensation. Due to their well‐exposed catalytic sites, morphology, and porous structure, exhibited significantly enhanced yield enantioselectivity compared bulk counterparts organic precursors. This research highlights efficient strategy species onto MONs, thereby unlocking immense potential heterogeneous

Language: Английский

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Sustainable development of anticancer and antidiabetic derivatives by solvent-free heterocyclization

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 20, 2024

Herein we have developed a heterogeneous catalyst for synthesizing various anticancer and antidiabetic derivatives via heterocyclic synthesis under solvent-free conditions at mild temperatures. This approach eliminates the need complex cleanup or column chromatography, thus minimizing waste production. Moreover, can be recovered reused up to multiple times without compromising product yields, demonstrating its sustainability environmental friendliness. Additionally, evaluated each synthetic derivative activities. Initial assays revealed that certain exhibit promising inhibition against human breast cancer cells (MCF7), suggesting their potential as lead structures future agents. Furthermore, synthesized were assessed activity, showing superior efficacy. Notably, containing –H, –CH₃, –OCH₃ substituents demonstrated excellent activity compared 5-fluorouracil (5-FU), while –H –Br showed notable activities over acarbose, highlighting therapeutic potential. Thus, our study presents highly effective sustainable polyhydroquinoline derivatives, emphasizing catalyst's dual benefits in organic medicinal chemistry applications.

Language: Английский

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Development of anticancer and antidiabetic polyhydroquinoline derivatives by solvent-free heterocyclization

Journal of Nanoparticle Research, Journal Year: 2024, Volume and Issue: 26(9)

Published: Sept. 1, 2024

Language: Английский

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