Access to Bicyclo[3.1.0]hexane and Cyclopenta[c]pyrazole Scaffolds via Solvent-Directed Divergent Reactivity of 5-Iodotriazoles

Organic Letters, Journal Year: 2024, Volume and Issue: 26(45), P. 9625 - 9630

Published: Nov. 6, 2024

Divergent access to bicyclo[3.1.0]hexane and cyclopenta[c]pyrazole scaffolds bearing azole azine units has been developed. The approach involves intramolecular cyclization of 5-iodo-1,2,3-triazoles acting as stable diazoimine precursors with concomitant noncatalytic (3 + 2)-cycloaddition. choice solvent allows control the outcome cascade transformation. developed procedure is simple cost-efficient allowed important heterocycles be obtained in one-pot various functional groups.

Language: Английский

Transformation of 5-acylated N-fluoroalkyl-1,2,3-triazoles to trifluoromethylated ring-fused isoquinolines, 1,3-oxazines, and 1,3-oxazin-6-ones via ketenimines

RSC Advances, Journal Year: 2024, Volume and Issue: 14(37), P. 26938 - 26942

Published: Jan. 1, 2024

A new synthetic approach towards trifluoromethylated heterocycles, based on the reaction of 5-acylated N -fluoroalkyl substituted 1,2,3-triazoles under microwave heating, proceeding via ketenimines is presented.

Language: Английский