Dual Temperature and pH Sensitive Poly(ethyl methacrylate‐co‐acrylamide) Nanogels Have Potential for Controlled Release of Doxorubicin
Orhun Hakkoymaz,
No information about this author
Hidayet Mazı
No information about this author
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(37)
Published: Sept. 30, 2024
Abstract
In
this
study,
the
synthesis
and
characterization
of
poly(ethyl
methacrylate‐
co
‐acrylamide)
(i.e.,
poly(EMA‐
‐AAm))
nanogels
loading
release
studies
doxorubicin
hydrochloride
were
carried
out.
The
was
out
using
emulsion
polymerization
technique
at
60
°C.
Swelling
experiments
showed
that
sensitive
to
temperature
pH
medium.
Zeta
sizer
analysis
results
synthesized
had
an
average
size
23.17
nm
PDI
value
0.270.
into
nanogels,
drug
capacity
(DLC)
nanogel
determined
as
32%
efficiency
(DLE)
77%.
Release
conducted
=
5.4
7.4
37
°C
percentage
17%
even
in
32
h
7.4,
82%
5
5.4.
different
temperatures
revealed
°C,
85%
39
89%
41
These
‐AAm)
can
be
used
targeted
controlled
increase
effects
while
reducing
side
effects.
Language: Английский
Self-Healable, Antimicrobial and Conductive Hydrogels Based on Dynamic Covalent Bonding with Silver Nanoparticles for Flexible Sensor
Polymers,
Journal Year:
2024,
Volume and Issue:
17(1), P. 54 - 54
Published: Dec. 29, 2024
Dynamic
hydrogels
have
attracted
considerable
attention
in
the
application
of
flexible
electronics,
as
they
possess
injectable
and
self-healing
abilities.
However,
it
is
still
a
challenge
to
combine
high
conductivity
antibacterial
properties
into
dynamic
hydrogels.
In
this
work,
we
fabricated
type
hydrogel
based
on
acylhydrazone
bonds
between
thermo-responsive
copolymer
silver
nanoparticles
(AgNPs)
functionalized
with
hydrazide
groups.
The
hybrid
exhibited
sol–gel
transition,
self-healable,
efficiency
was
over
92%.
Moreover,
displayed
antimicrobial
(6.85
S/m).
Notably,
hydrogel-based
sensors
strain
temperature
sensing
(22.05%/°C)
could
detect
human
motion
speech,
electrocardiographic
(ECG)
electromyography
(EMG)
signals.
Overall,
work
provides
simple
strategy
synthesize
AgNPs-based
multi-functions,
may
find
potential
applications
wearable
health
monitoring
speech
recognition.
Language: Английский