Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 14, 2024
ABSTRACT
We
developed
a
novel
hetero‐bimetallic
Fe(III)‐Mn(I)
complex
by
combining
hydroxyl
radicals
generating
Fe(III)‐Phenolato/Carboxylato
and
CO‐releasing
Mn(I)(CO)
3
complexes
to
achieve
dual‐modality
theranostic
tool
for
photoactivated
anticancer
therapy.
were
conjugated
through
the
amide
coupling
synthesize
bimetallic
(
[Fe‐Mn]
)
characterized
analytically
spectroscopically.
Various
photophysical
assays
have
confirmed
production
of
release
CO
when
biologically
benign
[
Fe‐Mn
]
is
activated
visible
light
(400–700
nm),
resulting
in
significant
increase
luminescence
intensity.
The
cytotoxic
potential
complex,
resulted
from
enrichment
ROS
A549
cells
with
photoindex
~35
leaving
HPL1D
unaffected.
probed
caspase
3/7‐dependent
apoptosis
on
photoactivation
vitro.
([
Fe‐Mn]
provides
an
ideal
example
next‐generation
Journal of Drug Delivery Science and Technology,
Journal Year:
2024,
Volume and Issue:
100, P. 106007 - 106007
Published: Aug. 5, 2024
Globally,
cancer
is
regarded
as
a
severe
health
issue.
Among
these
breast
(BC),
the
second
most
common
kind
in
women
after
skin
cancer.
According
to
statistical
data
from
NIH
Cancer
Institute,
expected
number
of
cases
was
around
3
lakh
people,
with
7.1
%
fatality
rate.
The
rise
multidrug
resistance
(MDR)
British
Columbia
issue
it
lowers
effectiveness
existing
treatments.
Traditional
MDR
treatment
approaches
BC
have
drawbacks,
including
toxicity,
high
cost,
early
discharge,
restricted
drug
load
before
target,
and
poor
effectiveness.
Preventing
has
depended
heavily
on
developing
innovative
therapy
delivery
methods
utilizing
nanomedicine
new
diagnosing
treating
BC.
This
review
discusses
its
pathophysiology
relation
tumor
kinetics.
It
focuses
latest
therapeutic
over
traditional
like
Surgery,
Chemotherapy,
Nanomedicine,
Phototherapy,
Immunotherapy,
Gene
therapy.
also
describes
diagnostic
techniques
using
MRI/PET,
Mammography,
Microwave
Sensing,
In-silico
methods,
Molecular
techniques,
AI-machine
learning-based
tools.
discussed
limitations
nanoparticles
article
aims
identify
efficient
ways
diagnose
treat
prevent
recurrence.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 17, 2024
In
recent
decades,
nanotechnology
has
significantly
advanced
drug
delivery
systems,
particularly
in
targeting
subcellular
organelles,
thus
opening
new
avenues
for
disease
treatment.
Mitochondria,
critical
cellular
energy
and
health,
when
dysfunctional,
contribute
to
cancer,
neurodegenerative
diseases,
metabolic
disorders.
This
propelled
the
development
of
nanomedicines
aimed
at
precise
mitochondrial
modulate
their
function,
marking
a
research
hotspot.
review
delves
into
advancements
mitochondrial-targeted
nanotherapeutics,
with
comprehensive
focus
on
strategies,
nanocarrier
designs,
therapeutic
applications.
It
emphasizes
nanotechnology's
role
enhancing
by
overcoming
biological
barriers
optimizing
design
specific
targeting.
Strategies
exploiting
membrane
potential
differences
ligands
improve
accumulation
nanomedicines.
The
use
diverse
nanocarriers,
including
liposomes,
polymer
nanoparticles,
inorganic
tailored
effective
targeting,
shows
promise
anti-tumor
treatments.
addresses
challenges
future
directions
nanotherapy,
highlighting
need
precision,
reduced
toxicity,
clinical
validation.
Mitochondrial
nanotherapy
stands
forefront
offering
innovative
treatment
perspectives.
Ongoing
innovation
are
crucial
developing
more
modalities.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(16), P. 12653 - 12670
Published: Jan. 1, 2025
Hyaluronic
acid-coated
capecitabine
nanomicelles
enhance
drug
delivery
by
improving
permeability,
targeting
CD44
receptors,
and
inducing
dose-dependent
apoptosis
in
breast
cancer
cells,
offering
a
stable
efficient
therapy.
Journal of Microencapsulation,
Journal Year:
2024,
Volume and Issue:
41(6), P. 456 - 478
Published: July 11, 2024
There
are
around
24
distinct
lipid
vesicles
described
in
the
literature
that
similar
to
vesicular
systems
such
as
liposomes.
Liposome-like
structures
formed
by
combining
certain
amphiphilic
lipids
with
a
suitable
stabiliser.
Since
their
discovery
and
classification,
self-assembled
liposome-like
active
drug
delivery
vehicles
captured
researchers'
curiosity.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(11)
Published: Oct. 20, 2024
Abstract
Cancer
is
a
leading
cause
of
morbidity
and
mortality
worldwide,
an
increase
in
incidence
estimated
the
next
future,
due
to
population
aging,
which
requires
development
highly
tolerable
low‐toxicity
cancer
treatment
strategies.
The
use
nanotechnology
tailor
treatments
according
genetic
immunophenotypic
characteristics
patient's
tumor,
allow
its
targeted
release,
can
meet
this
need,
improving
efficacy
minimizing
side
effects.
Nanomedicine‐based
approach
for
diagnosis
rapidly
evolving
field.
Several
nanoformulations
are
currently
clinical
trials,
some
have
been
approved
marketed.
However,
their
large‐scale
production
still
hindered
by
in‐depth
debate
involving
ethics,
intellectual
property,
safety
health
concerns,
technical
issues,
costs.
Here,
we
survey
key
approaches,
with
specific
reference
organ‐on
chip
technology,
cutting‐edge
tools,
such
as
CRISPR/Cas9
genome
editing,
through
nanosystems
needs
personalized
diagnostics
therapy
patients.
An
update
provided
on
nanopharmaceuticals
marketed
those
undergoing
trials.
Finally,
discuss
emerging
avenues
field
challenges
be
overcome
transfer
nano‐based
precision
oncology
into
daily
life.
