Recent advances in the synthesis of anticancer pyrazole derivatives using microwave, ultrasound, and mechanochemical techniques

RSC Advances, Journal Year: 2025, Volume and Issue: 15(9), P. 7018 - 7038

Published: Jan. 1, 2025

Pyrazole and its derivatives have attracted considerable attention in pharmaceutical medicinal chemistry, as reflected their presence numerous FDA-approved drugs clinical candidates. This review presents a comprehensive analysis of articles published between 2014 2024, focusing on the microwave-, ultrasound-, mechanochemical-assisted synthesis pyrazole with anticancer activity. It explores synthetic methodologies, efficacy, molecular docking studies, underscoring significance drug discovery chemistry. Notably, microwave irradiation stands out most widely employed technique, providing high efficiency by significantly reducing reaction times while maintaining moderate temperatures. Ultrasound serves valuable alternative, particularly for processes that require milder conditions, whereas mechanochemical activation, though less frequently employed, offers distinct advantages terms sustainability.

Language: Английский

---

Ring opening and recyclization reactions with 3-functionalized chromones: Recent synthetic approaches for five, six and seven membered heterocycles

Synthetic Communications, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: Feb. 12, 2025

Language: Английский

---

Insight into the therapeutic potential of pyrazole‐thiazole hybrids: A comprehensive review

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Abstract Several pyrazole‐thiazole hybrids featuring two potentially bioactive pharmacophores with or without linker have been synthesized using the molecular hybridization approach as target structures by medicinal chemists to modulate multiple drug targets simultaneously. The presented review aims provide an overview of diversified and wide array pharmacological activities these bestowing anticancer, antifungal, antibacterial, analgesic, anti‐inflammatory, antioxidant, antitubercular, antiviral, antiparasitic, miscellaneous activities. structure–activity relationships potential mechanism action are also reviewed shed light on development more effective biotargeted candidates. This focuses latest research advances in biological profile reported from 2015 present, providing researchers a comprehensive platform rationally design develop promising hybrids.

Language: Английский

---

A green and efficient synthesis of alkyl 2-((5-hydroxy-1 H -pyrazole-4-carbonothioyl)thio)acetates via a one-pot, solvent-free reaction

Journal of Sulfur Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: Sept. 11, 2024

Language: Английский

---