Recent advances on anticancer activity of benzodiazine heterocycles through kinase inhibition

RSC Advances, Journal Year: 2025, Volume and Issue: 15(7), P. 5597 - 5638

Published: Jan. 1, 2025

This is an updated review for the anticancer activity of benzodiazine heterocyclic derivatives through kinase inhibition.

Language: Английский

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In silico exploration of Aloe Vera leaf compounds as dual AChE and BChE inhibitors for Alzheimer’s disease therapy

Current Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Rationale, in silico docking, ADMET profile, design, synthesis and cytotoxicity evaluations of phthalazine derivatives as VEGFR-2 inhibitors and apoptosis inducers

RSC Advances, Journal Year: 2024, Volume and Issue: 14(37), P. 27110 - 27121

Published: Jan. 1, 2024

New phthalazine derivatives as vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors were synthesized joined to different spacers including pyrazole, α,β-unsaturated ketonic fragment, pyrimidinone and/or pyrimidinthione.

Language: Английский

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Phthalazine Derivatives as VEGFR‐2 Inhibitors: Docking, ADMET, Synthesis, Design, Anticancer Evaluations, and Apoptosis Inducers

Drug Development Research, Journal Year: 2024, Volume and Issue: 86(1)

Published: Dec. 24, 2024

New phthalazine-derived inhibitors for VEGFR-2 were synthesized anticancer evaluations. Also, docking studies performed to explore the suggested binding orientations of novel derivatives inside site VEGFR-2. The achieved biological data extremely interrelated that study. In specific, derivative 3f was greatest effective compound against HepG2 and MCF-7 cancer cell lines with IC

Language: Английский

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