Development and Validation of Microwave-assisted Extraction for Phenolic Compound Profiling in Diverse Oyster Mushrooms (Pleurotus spp.) Sourced from Various Geographical Regions
Journal of Agriculture and Food Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 101754 - 101754
Published: Feb. 1, 2025
Language: Английский
Punica granatum L. Peel: Anticancer Activity on Hep3B, Drug‐likeness, ADMET Prediction, and Molecular Docking with EGFR‐TK
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(3)
Published: Jan. 1, 2025
Abstract
The
side
effects
of
the
cancer
treatment
medications
that
have
sparked
renewed
interest
in
herbal
formulation
research.
Due
to
its
high
phytochemical
content,
Punica
granatum
L.
(different
parts
pomegranate),
a
basic
traditional
medicine
source,
is
an
excellent
option
for
anticancer
In
this
study,
activity
(Hicaz
variety)
peel
extract
on
Hep3B
cell
line
was
determined
by
MTT
test.
results
showed
P.
cytotoxic
effect
(cancer)
but
no
AML12
(healthy).
To
explain
effect,
main
bioactive
components
peel,
which
are
ellagic
acid,
abscisic
ethyl
gallate,
phlorizin,
gallic
and
myricetin,
were
performed
docking
study
with
EGFR‐TK
(PDB
ID:
1M17).
poses
all
selected
compounds
bind
same
site
as
inhibitor
erlotinib,
while
acid
(−8.8
kcal/mol),
myricetin
(−8.9
phlorizin
(−8.7
kcal/mol)
lower
binding
energy.
Also,
drug
similarity,
physicochemical,
ADMET
properties
these
phenolic
evaluated.
All
indicated
could
be
potential
therapeutic
candidate
against
liver
cancer.
Language: Английский
Mechanistic Insights into the Anticancer Potential of Methoxyflavones Analogs: A Review
Molecules,
Journal Year:
2025,
Volume and Issue:
30(2), P. 346 - 346
Published: Jan. 16, 2025
2-phenylchromen-4-one,
commonly
known
as
flavone,
plays
multifaceted
roles
in
biological
response
that
can
be
abundantly
present
natural
sources.
The
methoxy
group
naturally
occurring
flavones
promotes
cytotoxic
activity
various
cancer
cell
lines
by
targeting
protein
markers,
facilitating
ligand-protein
binding
mechanisms
and
activating
cascading
downstream
signaling
pathways
leading
to
death.
However,
the
lipophilic
nature
of
these
analogs
is
a
key
concern
it
impacts
drug
membrane
transfer.
While
lipophilicity
crucial
for
efficacy,
excessive
effects
flavonoids
reduce
water
solubility
hinder
transport
target
sites.
Recent
vitro
studies
suggest
incorporation
polar
hydroxyl
groups
which
form
hydrogen
bonds
stabilize
free
radicals
may
help
overcome
challenges
associated
with
while
maintaining
their
essential
properties.
Naturally
coexisting
methoxyflavones,
this
review
explores
synergistic
role
hydroxy
moieties
through
bonding
capacity
maximizing
cytotoxicity
against
lines.
physicochemical
analysis
revealed
potential
intramolecular
interaction
favorable
electron
delocalization
region
between
both
improve
levels.
Together,
provides
useful
strategy
structure-activity
relationship
(SAR)
flavonoid
distinct
suggesting
optimal
functional
positioning
achieve
balanced
lipophilicity,
effective
bonding,
simultaneously
minimized
steric
hindrance
specific
types.
Language: Английский
Molecular Docking Appraisal of Pleurotus ostreatus Phytochemicals as Potential Inhibitors of PI3K/Akt Pathway for Breast Cancer Treatment
Bioinformatics and Biology Insights,
Journal Year:
2025,
Volume and Issue:
19
Published: Jan. 1, 2025
Introduction:
Breast
cancer
(BC)
is
a
heterogeneous
disease
involving
network
of
numerous
extracellular
signal
transduction
pathways.
The
phosphoinositide
3-kinase
(PI3K)/serine/threonine
kinase
(Akt)/mechanistic
target
rapamycin
(mTOR)
pathway
crucial
for
understanding
the
BC
development.
Phosphoinositide
3-kinase,
phosphatase
and
tensin
homolog
(PTEN),
mTOR,
Akt,
3-phosphoinositide-dependent
1
(PDK1),
FoxO1,
glycogen
synthase
3
(GSK-3),
mouse
double
minute
2
(MDM2),
H-Ras,
proapoptotic
B-cell
lymphoma
(BCL-2)
family
protein
(BAD)
proteins
are
key
drivers
this
potential
therapeutic
targets.
Pleurotus
ostreatus
an
edible
mushroom
that
rich
in
flavonoids
phenols
can
serve
as
inhibitors
PI3K/Akt/mTOR
pathway.
Aim:
This
study
evaluated
anticancer
properties
P
through
structure-based
virtual
screening
22
biologically
active
compounds
present
mushroom.
Method:
Model
optimization
was
carried
out
on
PI3K,
PTEN,
PDK1,
GSK-3,
MDM2,
BAD
molecular
docking
compounds/control
binding
pocket
were
simulated
AutoDock
Vina
PyRx.
drug
likeness,
pharmacokinetic,
pharmacodynamic
features
prospective
leads
all
anticipated.
Result:
Several
potent
selected
driver
identified
from
ostreatus.
Ellagic
acid
with
affinities
−8.0,
−8.1,
−8.2,
−6.2,
−7.1
kcal/mol
BAD,
respectively,
had
better
affinity
compared
their
reference
drugs.
Likewise,
apigenin
(−7.8
kcal/mol),
chrysin
quercetin
(−6.4
chlorogenic
(−6.2
kcal/mol)
to
H-Ras
proteins,
respectively.
Conclusion:
acid,
apigenin,
luteolin,
quercetin,
chrysin,
naringenin
phytochemicals
seen
lead
molecules
due
ability
strongly
bind
under
Analogs
these
also
be
designed
Language: Английский