Adaptive Alcohols-Alcohols Cross-Coupling via TFA Catalysis: Access of Unsymmetrical Ethers DOI Creative Commons

Chengxiu Liu,

Jiaxin Liang,

Yuqiu Liang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract Ethers are high value organic compounds widely applied in chemical industry, natural products, material, pharmaceuticals, argochemicals, as well modern synthesis. Herein, we report an adaptive TFA-catalyzed cross-coupling of alcohols with various oxygen nucleophiles (nitro-, halogen-, sulfur-, nitrogen-, aryl-, and alkynyl-substituted aliphatic alcohols), delivering diverse unsymmetrical ethers under mild conditions simple operation. This protocol features a broad range substrate scope catalytic efficiency (52 examples, up to 99% yield). The decagram scale performance one-step synthesis drug molecules evidenced the potential industrial production practicability this protocol.

Language: Английский

Adaptive alcohols-alcohols cross-coupling via TFA catalysis: access of unsymmetrical ethers DOI Creative Commons

Chengxiu Liu,

Jiaxin Liang,

Yuqiu Liang

et al.

BMC Chemistry, Journal Year: 2025, Volume and Issue: 19(1)

Published: Jan. 12, 2025

Ethers are high value organic compounds widely applied in chemical industry, natural products, material, pharmaceuticals, argochemicals, as well modern synthesis. Herein, we report an adaptive TFA-catalyzed cross-coupling of alcohols with various oxygen nucleophiles (nitro-, halogen-, sulfur-, nitrogen-, aryl-, and alkynyl-substituted aliphatic alcohols), delivering diverse unsymmetrical ethers under mild conditions simple operation. This protocol features a broad range substrate scope catalytic efficiency (54 examples, up to 99% yield). The decagram scale performance one-step synthesis drug molecules evidenced the potential industrial production practicability this protocol.

Language: Английский

Citations

0
Adaptive Alcohols-Alcohols Cross-Coupling via TFA Catalysis: Access of Unsymmetrical Ethers DOI Creative Commons

Chengxiu Liu,

Jiaxin Liang,

Yuqiu Liang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract Ethers are high value organic compounds widely applied in chemical industry, natural products, material, pharmaceuticals, argochemicals, as well modern synthesis. Herein, we report an adaptive TFA-catalyzed cross-coupling of alcohols with various oxygen nucleophiles (nitro-, halogen-, sulfur-, nitrogen-, aryl-, and alkynyl-substituted aliphatic alcohols), delivering diverse unsymmetrical ethers under mild conditions simple operation. This protocol features a broad range substrate scope catalytic efficiency (52 examples, up to 99% yield). The decagram scale performance one-step synthesis drug molecules evidenced the potential industrial production practicability this protocol.

Language: Английский

Citations

0