Design and synthesis of novel 2-(2-(4-bromophenyl)quinolin-4-yl)-1,3,4-oxadiazole derivatives as anticancer and antimicrobial candidates: in vitro and in silico studies DOI Creative Commons
Noha Ryad, Ayman Abo Elmaaty, Samy Selim

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(46), P. 34005 - 34026

Published: Jan. 1, 2024

Cancer is the second leading cause of death globally, surpassed only by heart disease. Moreover, bacterial infections remain a significant global health burden, contributing substantially to morbidity and mortality, especially among hospitalized patients. EGFR has emerged as prime therapeutic target due its pivotal role in driving uncontrolled cell growth survival across numerous cancer types. In addition, DNA gyrase represents promising for development novel antimicrobial agents. Therefore, we aimed design synthesize new multi-target quinoline hybrids (7-17e) capable acting anti-proliferative agents inhibiting microbial gyrase, respectively. The inhibitory potential synthesized compounds was determined using

Language: Английский

Exploring β-carboline hybrids and their derivatives: A review on synthesis and anticancer efficiency DOI

Nur Fatihah Sulaiman,

Siti Zafirah Zulkifli, Aimi Suhaily Saaidin

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 288, P. 117412 - 117412

Published: Feb. 18, 2025

Language: Английский

Citations

0
Novel Quinolin-4-ylcarbonylhydrazine Having N-(3-Arylacryloyl) Moiety: Design, Synthesis and Biological Evaluation as Potential Cytotoxic Agents against MDA-MB-231 via Tubulin Assembly Inhibition DOI
Hany M. Abd El‐Lateef,

Tahani H. Alharbi,

Eman Fayad

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1321, P. 140214 - 140214

Published: Sept. 27, 2024

Language: Английский

Citations

1
Design and synthesis of novel 2-(2-(4-bromophenyl)quinolin-4-yl)-1,3,4-oxadiazole derivatives as anticancer and antimicrobial candidates: in vitro and in silico studies DOI Creative Commons
Noha Ryad, Ayman Abo Elmaaty, Samy Selim

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(46), P. 34005 - 34026

Published: Jan. 1, 2024

Cancer is the second leading cause of death globally, surpassed only by heart disease. Moreover, bacterial infections remain a significant global health burden, contributing substantially to morbidity and mortality, especially among hospitalized patients. EGFR has emerged as prime therapeutic target due its pivotal role in driving uncontrolled cell growth survival across numerous cancer types. In addition, DNA gyrase represents promising for development novel antimicrobial agents. Therefore, we aimed design synthesize new multi-target quinoline hybrids (7-17e) capable acting anti-proliferative agents inhibiting microbial gyrase, respectively. The inhibitory potential synthesized compounds was determined using

Language: Английский

Citations

0