Synthesis and Characterization of a Fluorinated Schiff Base from Benzimidazole and Its Metal Complexes for Antimicrobial and UV-Protective Cotton Fabrics DOI Open Access
Ahmed N. Al‐Hakimi, Tahani M. Alresheedi, Reema A. Albarrak

et al.

Coatings, Journal Year: 2025, Volume and Issue: 15(4), P. 380 - 380

Published: March 24, 2025

Due to the lack of UV-protective properties for cotton textiles and potential cause microbes their users, we synthesized benzimidazole Schiff base derivative (BZI) namely N-((1H-benzo[d]imidazol-2-yl)methyl)-1-(4-fluorophenyl)methanimine V(III), Fe(III), Co(II), Ni(II), Cu(II) complexes as UV protection antimicrobial agents textile. Several techniques investigated these compounds: 1H, 13C NMR, IR, UV–Vis, elemental analysis, DTA, TGA. The ligand behaved a bidentate ligand. prepared its are used treat fabrics (CFs) by immersing fabric in solution samples under ultrasonic. treated were using IR SEM-EDX analysis. UPF values obtained. results showed that with Fe(III) had excellent 50+. disc diffusion method evaluated fabric’s activity. antifungal activities CFs demonstrated Co(II)-BZI-CF was active on C. albicans an inhibition zone 12 mm, while other inactive A. flavus. V(III)-BZI-CF Fe(III)-BZI-CF no activity against S. aureus E. coli bacteria gave between 10 17 mm. Unlike previous studies primarily focused either or metal separately, this research integrates both functionalities synthesizing applying them textiles, demonstrating enhanced selective

Language: Английский

Benzimidazole(s): synthons, bioactive lead structures, total synthesis, and the profiling of major bioactive categories DOI Creative Commons
Lotfi M. Aroua, Fahad M. Alminderej, Hind R. Almuhaylan

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(10), P. 7571 - 7608

Published: Jan. 1, 2025

Benzimidazole, a fused bicyclic compound with benzene and pentacyclic 1,3-diazole moeities, has simple aromatic heterocyclic structure. The moiety become an indispensable anchor for the development of new pharmacologically active products, yielded several therapeutic agents anticancer, antihypertensive, antimicrobial, antifungal antiulcer effects. Benzimidazoles, as synthetically feasible pharmacophoric synthons, have been relentlessly pursued preparation analogues derivatives, they successfully developed into some most sought-after vital pharmacophores drug discovery. use varied substituents differing patterns around benzimidazole nucleus provided wide spectrum biological activities. In addition, constitutes building block production drugs, candidates, chemical entities, lead molecules. importance this bioactivity, e.g., antibacterial, antitubercular, antidiabetic, antifungal, anti-inflammatory, analgesic, antioxidant, antihistaminic, antimalarial activity, led us to take note provide overview synthetic approaches various derivatives together their actions. This review is projected further assist in design benzimidazole-based compounds optimized products towards drug-development strategies.

Language: Английский

Citations

2

Synthesis and Characterization of a Fluorinated Schiff Base from Benzimidazole and Its Metal Complexes for Antimicrobial and UV-Protective Cotton Fabrics DOI Open Access
Ahmed N. Al‐Hakimi, Tahani M. Alresheedi, Reema A. Albarrak

et al.

Coatings, Journal Year: 2025, Volume and Issue: 15(4), P. 380 - 380

Published: March 24, 2025

Due to the lack of UV-protective properties for cotton textiles and potential cause microbes their users, we synthesized benzimidazole Schiff base derivative (BZI) namely N-((1H-benzo[d]imidazol-2-yl)methyl)-1-(4-fluorophenyl)methanimine V(III), Fe(III), Co(II), Ni(II), Cu(II) complexes as UV protection antimicrobial agents textile. Several techniques investigated these compounds: 1H, 13C NMR, IR, UV–Vis, elemental analysis, DTA, TGA. The ligand behaved a bidentate ligand. prepared its are used treat fabrics (CFs) by immersing fabric in solution samples under ultrasonic. treated were using IR SEM-EDX analysis. UPF values obtained. results showed that with Fe(III) had excellent 50+. disc diffusion method evaluated fabric’s activity. antifungal activities CFs demonstrated Co(II)-BZI-CF was active on C. albicans an inhibition zone 12 mm, while other inactive A. flavus. V(III)-BZI-CF Fe(III)-BZI-CF no activity against S. aureus E. coli bacteria gave between 10 17 mm. Unlike previous studies primarily focused either or metal separately, this research integrates both functionalities synthesizing applying them textiles, demonstrating enhanced selective

Language: Английский

Citations

0