Benzimidazole(s): synthons, bioactive lead structures, total synthesis, and the profiling of major bioactive categories
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(10), P. 7571 - 7608
Published: Jan. 1, 2025
Benzimidazole,
a
fused
bicyclic
compound
with
benzene
and
pentacyclic
1,3-diazole
moeities,
has
simple
aromatic
heterocyclic
structure.
The
moiety
become
an
indispensable
anchor
for
the
development
of
new
pharmacologically
active
products,
yielded
several
therapeutic
agents
anticancer,
antihypertensive,
antimicrobial,
antifungal
antiulcer
effects.
Benzimidazoles,
as
synthetically
feasible
pharmacophoric
synthons,
have
been
relentlessly
pursued
preparation
analogues
derivatives,
they
successfully
developed
into
some
most
sought-after
vital
pharmacophores
drug
discovery.
use
varied
substituents
differing
patterns
around
benzimidazole
nucleus
provided
wide
spectrum
biological
activities.
In
addition,
constitutes
building
block
production
drugs,
candidates,
chemical
entities,
lead
molecules.
importance
this
bioactivity,
e.g.,
antibacterial,
antitubercular,
antidiabetic,
antifungal,
anti-inflammatory,
analgesic,
antioxidant,
antihistaminic,
antimalarial
activity,
led
us
to
take
note
provide
overview
synthetic
approaches
various
derivatives
together
their
actions.
This
review
is
projected
further
assist
in
design
benzimidazole-based
compounds
optimized
products
towards
drug-development
strategies.
Language: Английский
Synthesis and Characterization of a Fluorinated Schiff Base from Benzimidazole and Its Metal Complexes for Antimicrobial and UV-Protective Cotton Fabrics
Coatings,
Journal Year:
2025,
Volume and Issue:
15(4), P. 380 - 380
Published: March 24, 2025
Due
to
the
lack
of
UV-protective
properties
for
cotton
textiles
and
potential
cause
microbes
their
users,
we
synthesized
benzimidazole
Schiff
base
derivative
(BZI)
namely
N-((1H-benzo[d]imidazol-2-yl)methyl)-1-(4-fluorophenyl)methanimine
V(III),
Fe(III),
Co(II),
Ni(II),
Cu(II)
complexes
as
UV
protection
antimicrobial
agents
textile.
Several
techniques
investigated
these
compounds:
1H,
13C
NMR,
IR,
UV–Vis,
elemental
analysis,
DTA,
TGA.
The
ligand
behaved
a
bidentate
ligand.
prepared
its
are
used
treat
fabrics
(CFs)
by
immersing
fabric
in
solution
samples
under
ultrasonic.
treated
were
using
IR
SEM-EDX
analysis.
UPF
values
obtained.
results
showed
that
with
Fe(III)
had
excellent
50+.
disc
diffusion
method
evaluated
fabric’s
activity.
antifungal
activities
CFs
demonstrated
Co(II)-BZI-CF
was
active
on
C.
albicans
an
inhibition
zone
12
mm,
while
other
inactive
A.
flavus.
V(III)-BZI-CF
Fe(III)-BZI-CF
no
activity
against
S.
aureus
E.
coli
bacteria
gave
between
10
17
mm.
Unlike
previous
studies
primarily
focused
either
or
metal
separately,
this
research
integrates
both
functionalities
synthesizing
applying
them
textiles,
demonstrating
enhanced
selective
Language: Английский