Reverse Block Sequence in Self-Immolative Poly(benzyl ether)-Based Amphiphiles for Tailoring End Groups and Self-Assembly Behavior DOI

Ji Woo Kim,

Tae-Il Kang,

Eunpyo Choi

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

This paper reports a modular design of self-immolative poly(benzyl ether) (PBE) amphiphiles that allows precise control over polymer chain structure, end-group placement, and degradation behavior. By tuning block sequences exposing reactive end groups, these undergo efficient head-to-tail depolymerization upon external stimuli. Structural variations in the monomers enable micelle formation with groups displayed on surface, while carboxylate content hydrophilic influences global morphology. The resulting micelles are degradable aqueous environments can transform into spherical structures when combined conventional surfactants. As proof concept, small-molecule cargos were successfully loaded released from mixed demand. platform offers versatile route to create functional, stimulus-responsive surfactants tunable assembly, degradation, controlled release capabilities.

Language: Английский

Reverse Block Sequence in Self-Immolative Poly(benzyl ether)-Based Amphiphiles for Tailoring End Groups and Self-Assembly Behavior DOI

Ji Woo Kim,

Tae-Il Kang,

Eunpyo Choi

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

This paper reports a modular design of self-immolative poly(benzyl ether) (PBE) amphiphiles that allows precise control over polymer chain structure, end-group placement, and degradation behavior. By tuning block sequences exposing reactive end groups, these undergo efficient head-to-tail depolymerization upon external stimuli. Structural variations in the monomers enable micelle formation with groups displayed on surface, while carboxylate content hydrophilic influences global morphology. The resulting micelles are degradable aqueous environments can transform into spherical structures when combined conventional surfactants. As proof concept, small-molecule cargos were successfully loaded released from mixed demand. platform offers versatile route to create functional, stimulus-responsive surfactants tunable assembly, degradation, controlled release capabilities.

Language: Английский

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