Utilizing the Pentadehydro-Diels–Alder Reaction for Polycyclic Aromatic Compound Synthesis: Diels–Alder-Based Linker Transformation DOI Creative Commons
Ying Xia, Qi Liang, Chenlong Zhu

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1617 - 1617

Published: April 4, 2025

This study introduces a traceless linker strategy for pentadehydro-Diels–Alder (PDDA) cyclization, in which the sulfide/sulfone is strategically repurposed as diene surrogate. As excellent electron-donating dienes, these linkers react with electron-deficient alkenes and alkynes, resulting series of highly selective cyclization products. cascade reaction efficiently integrates PDDA transformation, formally eliminating need permanent structural constraints. By exploiting intrinsic reactivity linker, this offers robust versatile approach to constructing complex polycyclic aromatic architectures, providing powerful tool organic synthesis.

Language: Английский

Utilizing the Pentadehydro-Diels–Alder Reaction for Polycyclic Aromatic Compound Synthesis: Diels–Alder-Based Linker Transformation DOI Creative Commons
Ying Xia, Qi Liang, Chenlong Zhu

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1617 - 1617

Published: April 4, 2025

This study introduces a traceless linker strategy for pentadehydro-Diels–Alder (PDDA) cyclization, in which the sulfide/sulfone is strategically repurposed as diene surrogate. As excellent electron-donating dienes, these linkers react with electron-deficient alkenes and alkynes, resulting series of highly selective cyclization products. cascade reaction efficiently integrates PDDA transformation, formally eliminating need permanent structural constraints. By exploiting intrinsic reactivity linker, this offers robust versatile approach to constructing complex polycyclic aromatic architectures, providing powerful tool organic synthesis.

Language: Английский

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