Electro-Oxidative Three-Component Synthesis of 3,5-Disubstituted-1,2,4-Thiadiazoles from Amines, Amidines, and CS₂

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

1,2,4-Thiadiazoles, a significant class of heterocyclic compounds, are widely found in biologically active molecules. Herein, we report green electrochemical three-component reaction amines, amidines, and CS2 for the effective synthesis 3,5-disubstituted-1,2,4-thiadiazoles under metal- oxidant-free conditions. Both aliphatic aryl amines well-tolerated at room temperature simple undivided cell. A series 1,2,4-thiadiazoles prepared with excellent functional groups.

Language: Английский

Switching engineered Vitreoscilla hemoglobin into carbene transferase for enantioselective S H insertion

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134756 - 134756

Published: Aug. 13, 2024

Language: Английский

Enzymatic and convenient synthesis of polyhydroxyalkyl pyrroles from unprotected sugars, benzoylacetonitriles, and NH4OAc/Benzylamines in water

Molecular Catalysis, Journal Year: 2024, Volume and Issue: 572, P. 114725 - 114725

Published: Dec. 1, 2024

Language: Английский