Luminescent Lanthanides in Biorelated Applications: From Molecules to Nanoparticles and Diagnostic Probes to Therapeutics DOI Creative Commons
Carlson Alexander, Zhilin Guo,

P.B. Glover

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Lanthanides are particularly effective in their clinical applications magnetic resonance imaging and diagnostic assays. They have open-shell 4f electrons that give rise to characteristic narrow, line-like emission which is unique from other fluorescent probes biological systems. Lanthanide luminescence signal offers selection of detection pathways based on the choice ion visible near-infrared with long lifetimes lend themselves time-resolved measurements for optical multiplexing schemes novel bioimaging applications. The delivery lanthanide agents cells allows localized bioresponsive activity therapies. Detection region spectrum coupled technological advances microscopies opens new avenues deep-tissue surgical interventions. This review focuses different ways can be exploited nucleic acid enzyme detection, anion recognition, cellular imaging, tissue photoinduced therapeutic We focused hierarchy designs include luminescent lanthanides as biology considering coordination complexes, multimetallic systems metal-organic frameworks nanoparticles highlighting strategies downshifting, upconversion revealing some opportunities challenges offer potential further development field.

Language: Английский

Advances in the Design of Photoactivatable Metallodrugs: Excited State Metallomics DOI Creative Commons
Huayun Shi, Rafael C. Marchi, Peter J. Sadler

et al.

Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Photoactivatable metal complexes offer the prospect of novel drugs with low side effects and new mechanisms action to combat resistance current therapy. We highlight recent progress in design platinum, ruthenium, iridium, gold other transition complexes, especially for applications as anticancer anti‐infective agents. In particular, understanding excited state chemistry related identification bioactive species (excited metallomics/pharmacophores) is important. metallodrugs are classified here photocatalysts, photorelease agents ligand‐activated Their activation wavelengths, cellular action, experimental theoretical metallomics states photoproducts discussed explore strategies investigation photoactivatable metallodrugs. These have potential clinical Photodynamic Therapy (PDT), Photoactivated Chemotherapy (PACT) Photothermal (PTT).

Language: Английский

Citations

1
Advances in the Design of Photoactivatable Metallodrugs: Excited State Metallomics DOI Creative Commons
Huayun Shi, Rafael C. Marchi, Peter J. Sadler

et al.

Angewandte Chemie, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Photoactivatable metal complexes offer the prospect of novel drugs with low side effects and new mechanisms action to combat resistance current therapy. We highlight recent progress in design platinum, ruthenium, iridium, gold other transition complexes, especially for applications as anticancer anti‐infective agents. In particular, understanding excited state chemistry related identification bioactive species (excited metallomics/pharmacophores) is important. metallodrugs are classified here photocatalysts, photorelease agents ligand‐activated Their activation wavelengths, cellular action, experimental theoretical metallomics states photoproducts discussed explore strategies investigation photoactivatable metallodrugs. These have potential clinical Photodynamic Therapy (PDT), Photoactivated Chemotherapy (PACT) Photothermal (PTT).

Language: Английский

Citations

0
Luminescent Lanthanides in Biorelated Applications: From Molecules to Nanoparticles and Diagnostic Probes to Therapeutics DOI Creative Commons
Carlson Alexander, Zhilin Guo,

P.B. Glover

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Lanthanides are particularly effective in their clinical applications magnetic resonance imaging and diagnostic assays. They have open-shell 4f electrons that give rise to characteristic narrow, line-like emission which is unique from other fluorescent probes biological systems. Lanthanide luminescence signal offers selection of detection pathways based on the choice ion visible near-infrared with long lifetimes lend themselves time-resolved measurements for optical multiplexing schemes novel bioimaging applications. The delivery lanthanide agents cells allows localized bioresponsive activity therapies. Detection region spectrum coupled technological advances microscopies opens new avenues deep-tissue surgical interventions. This review focuses different ways can be exploited nucleic acid enzyme detection, anion recognition, cellular imaging, tissue photoinduced therapeutic We focused hierarchy designs include luminescent lanthanides as biology considering coordination complexes, multimetallic systems metal-organic frameworks nanoparticles highlighting strategies downshifting, upconversion revealing some opportunities challenges offer potential further development field.

Language: Английский

Citations

0