Pd-Catalyzed Divergent Site-Selective Difluoromethylation and Difluoromethylcarbonylation of Aryl Sulfonium Salts

ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(18), P. 13557 - 13566

Published: Aug. 28, 2024

The incorporation of the difluoromethyl (CF2H) group into arenes has increasingly been recognized as important in drug discovery. Herein, we report a divergent cross-coupling method for constructing both aryl difluoromethanes and difluoroketones from thianthrenium salts. Site selectivity Negishi-type coupling C1 insertion reactions was achieved under palladium catalysis. Both transformations proceed with broad functional tolerance, enabling late-stage difluoromethylation difluoromethylcarbonylation complex molecules. synthetic utility this demonstrated by synthesizing four pharmaceutical analogues same precursor applying it downstream functionalization difluoroketones.

Language: Английский

Fe3O4@SiO2-DHB/DI(S-NH)-Pd(0) nanocomposite: a novel, efficient, and reusable heterogeneous catalyst for carbonylative preparation of N-aryl amides

BMC Chemistry, Journal Year: 2025, Volume and Issue: 19(1)

Published: March 15, 2025

N-aryl amides hold significant importance in organic chemistry due to their widespread presence pharmaceuticals, agrochemicals, and various bioactive compounds. As a result, catalysts preparation methodologies for amide derivatives have long been target of active investigation interest. In the current work, simple accessible route was adopted magnetic catalyst [Fe3O4@SiO2-DHB/DI(S-NH)-Pd (0)] then its catalysis three-component synthesis via carbonylation reaction between aryl iodides amines examined. experiments, efficiency producing range with high yields short under mild conditions unequivocally confirmed, confirmed through experiments. High desired compound ease separation, reusability catalysts, conditions, accommodation substrates, thorough analysis determination produced compounds characterization purification taken as key features this work.

Language: Английский

Application of Fe3O4@SiO2-Phen-Pd(0) Nanocomposite as an Efficient and Reusable Catalyst for Ecofriendly Synthesis of Benzothiazole Amides

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Language: Английский