ACS Bio & Med Chem Au, Journal Year: 2024, Volume and Issue: 5(1), P. 16 - 30

Published: Nov. 27, 2024

Cytochrome P450 enzymes catalyze a large number of oxidative transformations that are responsible for natural product synthesis. Recent studies have revealed their unique ability to the formation C-N and C-S bonds, broadening biosynthetic applications. However, enzymatic mechanisms behind these reactions still unclear. This review focuses on theoretical insights into P450-catalyzed bond formation. The key roles conformational dynamics substrate radicals, influenced by enzyme environment, in modulating selectivity reactivity highlighted. Understanding reaction offers valuable guidance engineering design

Language: Английский