Recent Advances for Synthesis and Bioapplications of Polymethine Cyanines DOI
Ziyue Yang, Qihang Sun,

Luyang Ji

et al.

Asian Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Abstract Polymethine cyanine dyes have witnessed significant advancements in bioimaging and phototherapy due to their optical properties ease of modification. This review categorizes introduces typical synthesis Cy3, Cy5, Cy7 longer polymethine dyes, highlights organic‐specific in‐cell cyanines via the newly‐established pseudo‐trimerization method using a single exogenous precursor activatable by visible light, free radicals or reactive oxygen species. Further discussions delve into functionalization strategies structure‐activity relationships summarizes bioapplications fluorescence imaging, multimodal assisted diagnosis treatments, aiming unlock full potential scientific research clinical translation.

Language: Английский

A STEDable BF2-Azadipyrromethene Fluorophore for Nuclear Membrane and Associated Endoplasmic Reticulum Imaging DOI Creative Commons
Anaïs C. Bourgès, Massimiliano Garrè, Dan Wu

et al.

Membranes, Journal Year: 2025, Volume and Issue: 15(1), P. 9 - 9

Published: Jan. 1, 2025

The endoplasmic reticulum and the internal nuclear compartments are intrinsically connected through membrane, pores lamina. High resolution imaging of each these cellular features concurrently remains a significant challenge. To that end we have developed new molecular membrane-endoplasmic (NM-ER) staining fluorophore with emission maxima at 650 nm. NM-ER is compatible fixed live cell stimulated depletion microscopy (STED) showing improvement in when compared to comparable confocal laser scanning microscopy. versatility was illustrated its use other fluorophores for co-imaging DNA, lamina allowing abnormalities be identified. alone, or region labels could an important tool investigation transport associated processes.

Language: Английский

Citations

0
A novel small-molecule fluorescent probe caused by minimal structural modifications for specific staining of the cell nuclear membrane DOI
Wendong Jin, Liu Yang, Qing Lü

et al.

Chemical Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The nuclear membrane is a double-layered structure that physically protects the cell's DNA from chemical reactions occurring in other parts of cell. In this study, we present first brand-new small-molecule fluorescent probe selectively stains membrane, allowing for visualization morphology without interfering with DNA's activity.

Language: Английский

Citations

0
Recent Advances for Synthesis and Bioapplications of Polymethine Cyanines DOI
Ziyue Yang, Qihang Sun,

Luyang Ji

et al.

Asian Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Abstract Polymethine cyanine dyes have witnessed significant advancements in bioimaging and phototherapy due to their optical properties ease of modification. This review categorizes introduces typical synthesis Cy3, Cy5, Cy7 longer polymethine dyes, highlights organic‐specific in‐cell cyanines via the newly‐established pseudo‐trimerization method using a single exogenous precursor activatable by visible light, free radicals or reactive oxygen species. Further discussions delve into functionalization strategies structure‐activity relationships summarizes bioapplications fluorescence imaging, multimodal assisted diagnosis treatments, aiming unlock full potential scientific research clinical translation.

Language: Английский

Citations

0