Natural and Designed Cyclic Peptides as Potential Antiviral Drugs to Combat Future Coronavirus Outbreaks DOI Creative Commons

Hilarie Uwamahoro,

Willard E. Collier,

Toufic O. Nashar

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(8), P. 1651 - 1651

Published: April 8, 2025

The COVID-19 pandemic has underscored the need for effective and affordable antiviral drugs. Anthropogenic activities have increased interactions among humans, animals, wildlife, contributing to emergence of new re-emerging viral diseases. RNA viruses pose significant challenges due their rapid mutation rates, high transmissibility, ability adapt host immune responses treatments. World Health Organization identified several diseases (COVID-19, Ebola, Marburg, Zika, others), all caused by viruses, designated as being priority concern potential causes future pandemics. Despite advances in treatments, many lack specific therapeutic options, more importantly, there is a paucity broad-spectrum Additionally, costs current treatments such Remdesivir Paxlovid highlight Cyclic peptides from natural sources or designed through molecular modeling shown promise drugs with stability, low toxicity, target specificity, resistance properties. This review emphasizes urgent develop highlights cyclic sustainable solution combat Further research into these compounds could provide weapon address gaps drug development.

Language: Английский

Natural and Designed Cyclic Peptides as Potential Antiviral Drugs to Combat Future Coronavirus Outbreaks DOI Creative Commons

Hilarie Uwamahoro,

Willard E. Collier,

Toufic O. Nashar

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(8), P. 1651 - 1651

Published: April 8, 2025

The COVID-19 pandemic has underscored the need for effective and affordable antiviral drugs. Anthropogenic activities have increased interactions among humans, animals, wildlife, contributing to emergence of new re-emerging viral diseases. RNA viruses pose significant challenges due their rapid mutation rates, high transmissibility, ability adapt host immune responses treatments. World Health Organization identified several diseases (COVID-19, Ebola, Marburg, Zika, others), all caused by viruses, designated as being priority concern potential causes future pandemics. Despite advances in treatments, many lack specific therapeutic options, more importantly, there is a paucity broad-spectrum Additionally, costs current treatments such Remdesivir Paxlovid highlight Cyclic peptides from natural sources or designed through molecular modeling shown promise drugs with stability, low toxicity, target specificity, resistance properties. This review emphasizes urgent develop highlights cyclic sustainable solution combat Further research into these compounds could provide weapon address gaps drug development.

Language: Английский

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