Bacteria-tumor symbiosis destructible novel nanocatalysis drug delivery systems for effective tumor therapy DOI

Jing Zang,

Yin Fang, Ziyuan Liu

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: 20(3), P. 305 - 318

Published: Dec. 30, 2024

Colorectal cancer (CRC) is a significant threat to human health. The dynamic equilibrium between probiotics and pathogenic bacteria within the gut microbiota crucial in mitigating risk of CRC. An overgrowth harmful microorganisms gastrointestinal tract can result an excessive accumulation bacterial toxins carcinogenic metabolites, thereby disrupting delicate balance microbiota. This disruption may lead alterations microbial composition, impairment mucosal barrier function, potential promotion abnormal cell proliferation, ultimately contribute progression Recently, research has indicated that intestinal presence Fusobacterium nucleatum (Fn) significantly influences onset, progression, metastasis Consequently, interaction CRC cells Fn presents promising strategy against Nanomaterials have been extensively utilized therapy infection control, demonstrating substantial treating bacteria-associated tumors. review begins by elucidating mechanisms occurrence CRC, with particular emphasis on clarifying intricate relationship Subsequently, we highlight strategies utilize nanomaterials disrupt association Overall, this offers valuable insight guidance for leveraging therapy.

Language: Английский

A Peptide‐Derived Aggregation‐Induced Emission Nanobioprobe: Unlocking Selective Detection of Fusobacterium nucleatum and Noninvasive Screening of Colorectal Cancer DOI Creative Commons
Hongyu Liu,

T.-C. Wu,

Yunjian Yu

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

ABSTRACT Colorectal cancer (CRC) screening and early diagnosis is an effective strategy for reducing CRC mortality. However, the current detection methods involve exorbitant costs complex procedures, which are inconvenient large‐scale screening. Given its high prevalence in malignant tissues feces of patients, Fusobacterium nucleatum ( F. ) has emerged as a crucial biomarker CRC. Herein, we propose ‐specific recognition diagnosis. A novel nanobioprobe (AIE‐Pep) with aggregation‐induced emission (AIE) characteristics was synthesized by conjugating red/near‐infrared (NIR) emissive AIE luminogen (AIEgen) FadA‐targeting peptide (ASANWTIQYND). The robust binding affinity between FadA on allows AIE‐Pep NPs to adhere selectively , emits strong red/NIR fluorescence. In model orthotopic CRC, can precisely localize around Moreover, demonstrated limit (LOD) 82.97 CFU/mL could significantly differentiate mice from those normal mice. Overall, this study presents pivotal approach specifically identifying holds immense potential

Language: Английский

Citations

1
Multifunctional nanodrug for simultaneously combating chemoresistance and immunosuppression in Fusobacterium nucleatum-associated colorectal cancer DOI
Xiaohui Li, Mengdi Wu, Yu Wu

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Dual‐Responsive PPy‐AIPH@LA Nanoplatform for Synergistic Photothermal and Thermodynamic Therapy of Colorectal Cancer DOI Open Access
Liang Zhang,

Jiahao Qian,

Xinyuan Zhang

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(10)

Published: March 1, 2025

Abstract In this study, we introduce a novel nanoplatform, polypyrrole (PPy)‐2,2′‐Azobis[2‐(2‐imidazolin‐2‐yl)propane] dihydrochloride (AIPH)@lauric acid (LA) (PPy‐AIPH@LA) nanoparticles (NPs), designed to overcome these limitations through synergistic photothermal therapy (PTT) and photodynamic (PDT). This dual‐responsive system incorporates PPy for efficient conversion, AIPH thermos‐responsive oxygen‐independent free radical generation, LA as thermally responsive encapsulation layer. The coating melts upon 808 nm near‐infrared laser irradiation, releasing radicals enable precise spatiotemporal activation of therapeutic effects. PPy‐AIPH@LA demonstrates exceptional conversion efficiency (55.74%) generates sufficient enhance PDT efficacy, even in hypoxic tumor microenvironments. vitro studies revealed concentration‐dependent cell ablation inhibition migration, while vivo experiments showed that the combined PTT‐PDT treatment achieved an impressive 90.7% growth rate mouse colon cancer cells CT‐26 murine model, with no significant systemic toxicity. Molecular analyses further modulations pathways associated metabolism, apoptosis, immune escape, highlighting comprehensive potential nanoplatform. These findings underscore safe, effective, minimally invasive nanotherapeutic platform combating CRC other solid tumors.

Language: Английский

Citations

0
Bacteria-tumor symbiosis destructible novel nanocatalysis drug delivery systems for effective tumor therapy DOI

Jing Zang,

Yin Fang, Ziyuan Liu

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: 20(3), P. 305 - 318

Published: Dec. 30, 2024

Colorectal cancer (CRC) is a significant threat to human health. The dynamic equilibrium between probiotics and pathogenic bacteria within the gut microbiota crucial in mitigating risk of CRC. An overgrowth harmful microorganisms gastrointestinal tract can result an excessive accumulation bacterial toxins carcinogenic metabolites, thereby disrupting delicate balance microbiota. This disruption may lead alterations microbial composition, impairment mucosal barrier function, potential promotion abnormal cell proliferation, ultimately contribute progression Recently, research has indicated that intestinal presence Fusobacterium nucleatum (Fn) significantly influences onset, progression, metastasis Consequently, interaction CRC cells Fn presents promising strategy against Nanomaterials have been extensively utilized therapy infection control, demonstrating substantial treating bacteria-associated tumors. review begins by elucidating mechanisms occurrence CRC, with particular emphasis on clarifying intricate relationship Subsequently, we highlight strategies utilize nanomaterials disrupt association Overall, this offers valuable insight guidance for leveraging therapy.

Language: Английский

Citations

0