Synergistic Dual Antibacterial Activity of Magnetite Hydrogels Doped with Silver DOI Creative Commons
Mohamad Wehbe, Rayan Kadah El Habbal, Jad Kaj

et al.

Langmuir, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

In this work, we utilized poly-

Language: Английский

Design of pH-Responsive Nanomaterials Based on the Tumor Microenvironment DOI Creative Commons

Yunheng Liu,

Lei Si, Yuxuan Jiang

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 705 - 721

Published: Jan. 1, 2025

The metabolic activity of tumor cells leads to the acidification surrounding microenvironment, which provides new strategies for application nanotechnology in cancer therapy.Researchers have developed various types pH-responsive nanomaterials based on acidic microenvironment.This review an in-depth discussion design mechanisms, drug-loading strategies, and pathways microenvironment-responsive nanodrug delivery systems.These materials trigger drug release upon reaching enhancing therapeutic targeting reducing toxicity healthy cells.pH-responsive include organic nanomaterials, inorganic composite nanomaterials.Additionally, this outlines prospects, challenges aiming promote development clinical translation field.

Language: Английский

Citations

3
Recent advances in hyaluronic acid-based hydrogels for diabetic wound healing DOI
Chenguang Liu,

Ronger Ai,

Bi-zhi Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140797 - 140797

Published: Feb. 7, 2025

Language: Английский

Citations

1
Advances in the development of medical dressings for the treatment of diabetic foot wounds DOI
Ming Cai, Zhao Liu,

Xun Sun

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155575 - 155575

Published: Sept. 7, 2024

Language: Английский

Citations

5
Stimulus-responsive smart bioactive glass composites for repair of complex tissue defects DOI Creative Commons

Yulian Yang,

Yonghao Qiu, Lin Cai

et al.

Theranostics, Journal Year: 2025, Volume and Issue: 15(5), P. 1760 - 1786

Published: Jan. 2, 2025

Smart biomaterials with active environmental responsiveness have attracted widespread attention in recent years. Previous studies on bioactive glass (BG) mainly focused the property of bioactivity, while little has been paid to smart response BG. Herein, we propose concept Bioactive Glass Composites (SBGC) which are capable actively responding endogenous disease microenvironment or exogenous physical stimuli, thereby enabling treatment tissue defect sites and ultimately promoting regeneration. In this review, characteristics SBGC different internal external environments described. Subsequently, applications complex repair tumors, infections, diabetes reviewed. By deeply analyzing progress fields, review will point out direction for research next-generation

Language: Английский

Citations

0
Immunomodulation effects of collagen hydrogel encapsulating extracellular vesicles derived from calcium silicate stimulated-adipose mesenchymal stem cells for diabetic healing DOI Creative Commons

Yen-Hong Lin,

Yeh Chen,

En‐Wei Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 27, 2025

Diabetic wounds are characterized by chronic inflammation, reduced angiogenesis, and insufficient collagen deposition, leading to impaired healing. Extracellular vesicles (EVs) derived from adipose-derived mesenchymal stem cells (ADSC) offer a promising cell-free therapeutic strategy, yet their efficacy immunomodulation can be enhanced through bioactivation. In this study, we developed calcium silicate (CS)-stimulated ADSC-derived EVs (CSEV) incorporated into hydrogels create sustained-release system for promoting diabetic wound CSEV exhibited protein content, surface marker expression, bioactive cargo enriched with pro-angiogenic anti-inflammatory factors. vitro, CSEV-loaded significantly reactive oxygen species production, promoted cell proliferation migration compared standard EV-loaded collagen. Cytokine profiling revealed the upregulation of cytokines extracellular matrix components, highlighting immunomodulatory regenerative potential. vivo, histological evaluation rabbit models treated superior reepithelialization organized indicating accelerated closure. These findings underscore potential as an innovative effective platform enhancing healing simultaneously addressing inflammation tissue regeneration.

Language: Английский

Citations

0
Emerging roles of hyaluronic acid hydrogels in cancer treatment and wound healing: A review DOI
Gang Wu,

Chunyan Zhong,

Xiaohui Tian

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140442 - 140442

Published: Jan. 1, 2025

Language: Английский

Citations

0
Smart self-healing hydrogel wound dressings for diabetic wound treatment DOI

Yuelin Hu,

Dejia Xv,

Chaoming Xie

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: Feb. 18, 2025

Diabetic wounds are difficult to treat clinically because they heal poorly, often leading severe complications such as infections and amputations. Hydrogels with smart self-healing properties show great promise for treating diabetic wounds. These hydrogels capable of continuously dynamically responding changes in the wound environment, feature improved mechanical qualities capacity self-heal damage. We explore latest developments healing this review. First, we systematically summarize obstacles then highlighted significance hydrogels, explaining their stimulus-responsive mechanisms design approaches, along applications addressing these challenges. Finally, discussed unresolved potential avenues future research. anticipate that review will facilitate continued refinement dressings, aiming broader clinical adoption.

Language: Английский

Citations

0
Bioinspired programmed antibiofilm strategies for accelerated wound healing via spatiotemporally controlled enzyme nanoreactors DOI
Jun-Tao Hu,

Yibing Huang,

Hao Hao

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113582 - 113582

Published: March 1, 2025

Language: Английский

Citations

0
Smart hydrogel: A new platform for cancer therapy DOI
Guo Li, Z. Fu, Haoran Li

et al.

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 340, P. 103470 - 103470

Published: March 7, 2025

Language: Английский

Citations

0
Four-in-one pH/glucose-responsive engineered hydrogel for diabetes wound healing DOI

Baojie Du,

Xiaofeng Ren,

Xiaozhe Wang

et al.

Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102725 - 102725

Published: March 25, 2025

Language: Английский

Citations

0