Academic Radiology, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: 24(11), P. 768 - 791
Published: Oct. 10, 2024
Language: Английский
Citations
11
Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)
Published: Dec. 4, 2024
Abstract The extracellular matrix (ECM)—and its mechanobiology—regulates key cellular functions that drive tumor growth and development. Accordingly, mechanotherapy is emerging as an effective approach to treat fibrotic diseases such cancer. Through restoring the ECM healthy‐like conditions, this treatment aims improve tissue perfusion, facilitating delivery of chemotherapies. In particular, manipulation gaining interest a valuable strategy for developing innovative treatments based on nanoparticles (NPs). However, further progress required; instance, it known presence dense ECM, which hampers penetration NPs, primarily impacts efficacy nanomedicines. Furthermore, most 2D in vitro studies fail recapitulate physiological deposition components. To address these issues, comprehensive understanding interactions between NPs needed. This review focuses main features complex interplay with NPs. Recent advances are discussed insights offered into how combination nanomedicine can help nanomaterials design advance their clinical translation.
Language: Английский
Citations
4
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Abstract The mechanical elasticity of lipid nanoparticles (LNPs) is crucial to their pharmaceutical performance. This study investigates how the interactions between LNPs, target cells, and macrophages affect internalization LNPs into cells at tumor sites. According our bio‐mechanical study, drug‐resistant breast cancer are stiffer than sensitive ones, while invasive softer; similarly, protumoral M2 softer M1 macrophages. Softer show increased cellular uptake in macrophages, with enhanced engulfment Additionally, presence promotes greater LNP by facilitating malignant nature cells. In addition, because engulf via an energy‐efficient fusion pathway but undergo clathrin‐mediated endocytosis, internalized more not M2. orthotopic models, penetrate tumors quickly, enhancing suppression, whereas permeate slowly prolonged retention tumors, supporting antitumor efficacy repeated dosing. These findings underscore importance optimizing delivery systems, offering insights for effective designs.
Language: Английский
Citations
0
Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 584 - 584
Published: April 12, 2025
Beyond the genomic and proteomic analysis of bulk single cancer cells, a new focus research is emerging that based on mechanical cells. Therefore, several biophysical techniques have been developed adapted. The characterization like human cell lines, started with their at mostly timepoint. A universal hypothesis has proposed cells need to be softer migrate invade tissues subsequently metastasize in targeted organs. Thus, softness suggested serve as physical marker for malignancy types. However, it turned out there exists opposite phenomenon, namely stiffer are more migratory invasive therefore lead metastases. These contradictory results question universality role malignant progression cancers. Another problem various used can affect properties making even difficult compare different studies. Apart from instrumentation, culture measurement conditions influence measurements. review highlights main advances discusses strength weaknesses approaches, questions whether passive still state-of-the art. Besides models, setups, microenvironment characteristics presented debated. Finally, combinatorial approaches determine potential tumors, such involvement ECM, homogeneous or heterogeneous association, biological multi-omics analyses, together dynamic-mechanical highlighted frontiers research.
Language: Английский
Citations
0
ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 7, 2025
Language: Английский
Citations
0
Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 271, P. 116985 - 116985
Published: Nov. 25, 2024
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 17, 2024
Abstract For mesenchymal stem cell (MSC) therapy to be effective, the vascular system may used deliver and steer cells target tissue. However, expanded MSCs in petri dishes are usually have a limited deformability commonly excluded by capillary networks when homing downstream organs via microcirculation. Here, we propose utilize specially designed 3D dextran hydrogels tuning microscopic heterogeneity of hydrogel composition make administrated mechanically comply with structure mechanics capillary. The dishes, microcosmically homogeneous (HOM) heterogeneous (HET) were investigated vitro measuring moduli through atomic force microscope (AFM), analyzing expression cytoskeletal protein flow cytometry fluorescent imaging. experimental results demonstrate progressive increase from 2D HOM-hydrogel derived cells, then HET-hydrogel cells. vivo mouse experiment indicates could deform accordingly pass easily reduced resistance inside organs. It is suggested that main destination hMSC microcirculation selected between spleen liver mice, depends on stimulus HOM or HET hydrogel, which lays potential foundation for modified MSC lesions
Language: Английский
Citations
0
Academic Radiology, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
0