Langmuir,
Journal Year:
2024,
Volume and Issue:
40(47), P. 25051 - 25060
Published: Nov. 12, 2024
The
fast,
and
highly
sensitive
estimation
of
cardiac
troponin
T
(cTnT)
is
crucial
for
the
early
identification
acute
myocardial
infarction
(AMI).
electrochemical
immunoassay-based
(EIB)
sensors
are
promising
this
purpose,
as
they
offer
precise
measurements
can
be
directly
assessed
in
intricate
matrices,
including
blood.
To
increase
sensitivity,
EIB
use
nanomaterials
or
amplification
processes,
which
laborious
to
develop.
With
this,
we
develop
an
immunosensor
detection
(cTnT).
sensing
platform
composed
functionalized
triangular
carbon
quantum
dots
stabilized
gold
nanoparticles
integrated
with
boron
nitride
nanosheets
(caf-TCQDs@AuNPs
on
HO-BNNS).
Ferrocene
carboxylic
acid
(Fc-COOH)
serves
signal
label.
composite
was
developed
examined
using
several
techniques
such
X-ray
diffraction
(XRD),
photoelectron
spectroscopy
(XPS),
transmission
electron
microscopy
(TEM),
cyclic
voltammetry,
chronocoulometry.
caf-TCQDs@AuNPs
supported
HO-BNNS,
have
a
large
surface
area
excellent
electrical
conductivity,
serve
effective
immobilization
anti-cTnT
monoclonal
antibodies
via
carbodiimide
coupling.
Fc-COOH,
functioning
label
through
oxidation
process,
HO-BNNS
establish
cTnT.
demonstrated
performance
determination
cTnT
under
optimal
conditions,
exhibiting
linearity
range
spanning
from
0.0001
100
ng
mL
Langmuir,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
The
detection
of
carbohydrate
antigen
19–9
(CA199),
a
critical
biomarker
for
pancreatic,
colorectal,
and
gastric
cancers,
is
essential
early
diagnosis
disease
monitoring.
Traditional
antibody-based
assays
CA199
are
limited
by
high
costs,
time-consuming
procedures,
susceptibility
to
nonspecific
interference.
This
study
presents
an
electrochemical
biosensor
based
on
multifunctional
poly(EDOT-PyBA-co-EDOT-PEG)
copolymer
designed
overcome
these
limitations.
integrates
pyridylboronic
acid
(PyBA)
moieties
specific
recognition
sialic
residues
poly(ethylene
glycol)
(PEG)
chains
antifouling
properties
within
conductive
PEDOT
framework.
By
eliminating
antibody
dependency,
the
reduces
enhances
stability,
simplifies
diagnostic
process.
Surface
characterization
confirmed
successful
incorporation
PyBA
PEG
units,
while
impedance
spectroscopy
enabled
sensitive
with
limit
0.05
U·mL–1
linear
response
range
from
40
U·mL–1.
Recovery
tests
in
spiked
human
serum
samples
demonstrated
excellent
accuracy
(97–109%
recovery),
validating
biosensor's
reliability
complex
biological
matrices.
rationally
provides
both
sensitivity
specificity
maintaining
resistance
biofouling
samples.
work
establishes
scalable,
cost-effective
platform
glycoprotein
detection,
advancing
field
clinical
diagnostics
cancer
Biosensors,
Journal Year:
2025,
Volume and Issue:
15(3), P. 139 - 139
Published: Feb. 23, 2025
Wound
healing
is
a
complicated
biological
process
that
important
for
restoring
tissue
integrity
and
function
after
injury.
Infection,
usually
due
to
bacterial
colonization,
significantly
complicates
this
by
hindering
the
course
of
enhancing
chances
systemic
complications.
Recent
advances
in
wearable
biosensors
have
transformed
wound
care
making
real-time
monitoring
biomarkers
such
as
pH,
temperature,
moisture,
infection-related
metabolites
like
trimethylamine
uric
acid.
This
review
focuses
on
recent
biosensor
technologies
designed
management.
Novel
sensor
architectures,
flexible
stretchable
electronics,
colorimetric
patches,
electrochemical
platforms,
enable
non-invasive
detection
changes
associated
with
wounds
high
specificity
sensitivity.
These
are
increasingly
combined
AI
analytics
based
smartphones
can
timely
personalized
interventions.
Examples
PETAL
patch
applies
multiple
sensing
mechanisms
wide-ranging
views
status
closed-loop
systems
connect
therapeutic
devices
automate
infection
control.
Additionally,
self-powered
tap
into
body
heat
or
energy
from
biofluids
themselves
avoid
any
external
batteries
thus
more
effective
field
use
limited
resources.
Internet
Things
connectivity
allows
further
support
remote
sharing
data,
supporting
telemedicine
applications.
Although
developed
relatively
rapidly
their
prospects
continue
expand,
regular
clinical
application
stalled
significant
challenges
regulatory,
cost,
patient
compliance,
technical
problems
related
accuracy,
biofouling,
power,
among
others,
need
be
addressed
innovative
solutions.
The
goal
synthesize
current
trends,
challenges,
future
directions
monitoring,
emphasis
potential
improve
outcomes
reduce
healthcare
burdens.
innovations
leading
way
toward
next-generation
bridging
advanced
materials
science,
biotechnology,
digital
health.
Diagnostics,
Journal Year:
2025,
Volume and Issue:
15(7), P. 940 - 940
Published: April 7, 2025
Coronary
artery
disease
(CAD)
is
one
of
the
primary
causes
morbidity
and
death
worldwide.
Premature
CAD
(pCAD)
term
used
to
describe
3-10%
occurrences
that
occur
in
people
under
45
Diagnostic
difficulties
arise
from
different
risk
factor
profiles
pCAD
late-onset
CAD.
Better
cardiovascular
prediction
younger
populations
has
been
made
possible
by
development
biomarker
detection
tools.
This
can
be
applied
a
diagnostic
tool,
including
electrochemical
biosensors,
which
have
predicted
instrumental
because
their
adaptability
for
point-of-care
applications
quicker
diagnoses.
These
biosensors
provide
efficient,
scalable,
reasonably
priced
solutions
quick
identification
tracking
Multiplex
adopted
as
viable
approach
early
diagnosis
assessment
due
constraints
using
single
diagnosis.
Thus,
this
study
looks
at
current
developments
biosensing
technology
discusses
established
new
cardiac
panels
identification.
